Meta AnalysisID 1911
人工髋关节相关钴中毒：一项系统评价
CRD42020215827
The present study aims to perform a systematic review of case reports describing cobalt intoxication after any type of hip arthroplasty to define the symptoms of cobalt toxicity and to determine a level of cobalt concent
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Record Fields
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- Meta Analysis Id
- 1911
- Evidence Id
- 10469
- Core Evidence Id
- 10469
- Source Meta Analysis Id
- 1851
- Herb2 Meta Analysis Id
- HBMA001851
- Crd Id
- CRD42020215827
- Title
- Prosthetic Hip Associated Cobalt Toxicity: a systematic review
- Review Question
- The present study aims to perform a systematic review of case reports describing cobalt intoxication after any type of hip arthroplasty to define the symptoms of cobalt toxicity and to determine a level of cobalt concentration when toxicity might occur
- Study Type Included
- Case reports of patients presenting with cobalt intoxication after hip arthroplasty, published in Dutch, English, German of Spanish.
- Condition Being Studied
- An increase in blood serum metal ion levels is seen after implantation of all MoM hip prosthesis due to release from the metal surface directly, more so during articulation and corrosion of the bearing surfaces. Corrosion of the bearing surface also occurs when a metal (cobalt-chromium) component is used during revision of a fractured ceramic head of fractured ceramig acetabular liner. The continuous exposure to metal ions can result in soft tissue reactions and raised metal ion concentrations in blood, serum and urine. Systematic complaints in patients with MoM arthroplasty is als known as Prosthetic Hip Associated Cobalt Toxicity and may lead to a variety of symptoms: neuro-ocular-, cardio- and thyroid toxicity. It is currently unknown which of these symptoms is most reported and at what level of cobalt concentrations symptoms occer.
- Participant
- Patient with any type of hip arthroplasty (metal-on-metal, ceramic-on-ceramic, ceramic-on-polyethylene, metal-on-polyethyelene)
- Animal
- Human Disease Modelled
- Intervention
- Presentation with cobalt toxicity
- Comparator Control
- This review does not focus on another intervention or a non-exposed controle group.
- Main Outcome
- The primary outcome are the reported symptoms of cobalt intoxication and the threshold concentration at which symptoms occur. Measures of effect Percentages in which symptoms occur, and a threshold concentration at which symptoms occur
- Outcome Measure
- Additional Outcome
- The secondary outcome is the clinical outcome after treatment of cobalt intoxication Measures of effect Secondary outcomes will be shown descriptively
- Study Method
- Systematic review, Other
- Keyword
- Arthroplasty, Replacement, Hip; Cobalt; Hip Prosthesis; Humans
- Contact
- Jetse Jelsma [email protected]
- Organisational Affiliation
- Zuyderland Medical Centre
- Funding Source
- The review is not sponsored by individuals, organizations, groups, companies or orther legal entities. Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span>
- Other Selection Criteria
- Final Publication
- Same Topic Review
- x
- Published Protocol
- Review Type
- Language
- English
- Country
- Netherlandsx
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-10-22
- Registration Date
- 2020-11-22
- Anticipated Start Date
- 2020-06-01
- Anticipated Completion Date
- 2021-03-01
- Title Cn
- 人工髋关节相关钴中毒：一项系统评价
- Title En
- Prosthetic Hip Associated Cobalt Toxicity: a systematic review
- Bilingual Status
- complete