Meta AnalysisID 1910
骨科植入物或职业暴露导致钴暴露与全因及特定部位癌症风险关联的评估：系统评价与Meta分析
CRD42020156681
Is there an association between exposures to CoCr alloy through orthopedic implants or cobalt particulates from workplace pollution and risk of all-cause cancer or site-specific cancers?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 1910
- Evidence Id
- 10468
- Core Evidence Id
- 10468
- Source Meta Analysis Id
- 1850
- Herb2 Meta Analysis Id
- HBMA001850
- Crd Id
- CRD42020156681
- Title
- Evaluation of the Association Between Cobalt Exposure through Orthopedic Implants or Occupational Exposure and the Risk of All-Cause and Site-Specific Cancer – A Systematic Review and Meta-Analysis.
- Review Question
- Is there an association between exposures to CoCr alloy through orthopedic implants or cobalt particulates from workplace pollution and risk of all-cause cancer or site-specific cancers?
- Study Type Included
- Primary epidemiology studies only - no review/meta-analyses When multiple studies reported findings from overlapping populations, only the most recently published paper with the larger sample size or with the longer follow-up period is included in this analysis to eliminate risk of duplicate data capture
- Condition Being Studied
- All-cause cancer and anatomy-specific cancers.
- Participant
- All persons with exposures to Cobalt or Cobalt chromium alloy, without any restriction.
- Animal
- Human Disease Modelled
- Intervention
- Two exposures of interest: 1) occupational exposure to environmental cobalt; 2) exposure to CoCr through artificial joint replacement with metal joints.
- Comparator Control
- General population, age/gender standardized, not exposed to Cobalt or CoCr alloy. When available, comparable groups (eg patients with implant that do not contain CoCr).
- Main Outcome
- Risk of cancer in populations exposed to cobalt (all-cause or site-specific) or risk of mortality from cancer (all-cause or site-specific). Measures of effect From time of first exposure to end of life. Effect measures may include standardized incidence or mortality ratios.
- Outcome Measure
- Additional Outcome
- N/A Measures of effect N/A
- Study Method
- Epidemiologic, Meta-analysis, Systematic review
- Keyword
- Cobalt; Humans; Neoplasms; Occupational Diseases; Occupational Exposure
- Contact
- Chantal Holy [email protected]
- Organisational Affiliation
- Johnson & Johnson
- Funding Source
- Johnson & Johnson
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- United States of America
- Review Stage
- Review Ongoing
- First Submission Date
- 2019-10-30
- Registration Date
- 2020-04-28
- Anticipated Start Date
- 2019-10-31
- Anticipated Completion Date
- 2021-12-31
- Title Cn
- 骨科植入物或职业暴露导致钴暴露与全因及特定部位癌症风险关联的评估：系统评价与Meta分析
- Title En
- Evaluation of the Association Between Cobalt Exposure through Orthopedic Implants or Occupational Exposure and the Risk of All-Cause and Site-Specific Cancer – A Systematic Review and Meta-Analysis.
- Bilingual Status
- complete