Meta AnalysisID 1903
阿莫西林或阿莫西林联合克拉维酸改善下颌第三磨牙手术术后结局的疗效：系统评价与Meta分析
CRD42022313604
Does the use of amoxicillin or amoxicillin and clavulanic acid improve postoperative outcomes in mandibular third molar surgery?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 1903
- Evidence Id
- 10461
- Core Evidence Id
- 10461
- Source Meta Analysis Id
- 1844
- Herb2 Meta Analysis Id
- HBMA001844
- Crd Id
- CRD42022313604
- Title
- Efficacy of amoxicillin or amoxicillin and clavulanic acid in improving postoperative outcomes in mandibular third molar surgery: A systematic review and meta-analysis
- Review Question
- Does the use of amoxicillin or amoxicillin and clavulanic acid improve postoperative outcomes in mandibular third molar surgery?
- Study Type Included
- RCTs
- Condition Being Studied
- The rate of postoperative infection reported after third molar surgery is in the range of 0.8% 4.2%. Numerous randomized controlled trials (RCTs) have evaluated the efficacy of different antibiotics in preventing postoperative infections but have failed to lead to a consensus among practitioners regarding the type of antibiotic to be used and the appropriateness of antibiotic prescription for third molar surgery. Third molar surgeries are frequently performed in healthy young adults with minimal or no infection of the associated teeth, based on the clinical impression that future complications may arise from these teeth. This approach has been rigorously criticized. Amoxicillin along with amoxicillin– clavulanic acid combination are amongst the antibiotics most preferred by dentists globally for the prevention of postoperative infection after third molar surgery. Unfortunately, antibiotic prescribing preference does not seem to follow an evidence-based approach, but shows regional variation. Antibiotic use in third molar surgery should be evidence-based and the evidence should include an evaluation of the effectiveness of a particular antibiotic and reflect all of the possible adverse outcomes of that antibiotic. Such evidence could contribute to a reduction in inappropriate prescription by providing appropriate evidence of the harms of antibiotic treatment, including the possibility of antibiotic resistance.
- Participant
- Patients undergoing mandibular third molar surgery
- Animal
- Human Disease Modelled
- Intervention
- Use of amoxicillin or amoxicillin and clavulanic acid
- Comparator Control
- Placebo or no drug
- Main Outcome
- Infection rates, pain, swelling and trismus
- Outcome Measure
- Additional Outcome
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Humans; Molar, Third
- Contact
- Xingguang Liu [email protected]
- Organisational Affiliation
- Cheeloo College of Medicine, Shandong University
- Funding Source
- Shandong Provincial Natural Science Foundation (Grant No. ZR2021MH195), Shandong Provincial Key Research and Development Plan (Grant No. 2019GSF108200)
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-02-27
- Registration Date
- 2022-03-30
- Anticipated Start Date
- 2022-02-27
- Anticipated Completion Date
- 2022-03-29
- Title Cn
- 阿莫西林或阿莫西林联合克拉维酸改善下颌第三磨牙手术术后结局的疗效：系统评价与Meta分析
- Title En
- Efficacy of amoxicillin or amoxicillin and clavulanic acid in improving postoperative outcomes in mandibular third molar surgery: A systematic review and meta-analysis
- Bilingual Status
- complete