Meta AnalysisID 1894
瓜氨酸单用或联合运动对老年人肌肉质量、肌力和身体功能的影响：系统评价（方案）
CRD42019145681
Objective: To summarize, with a systematic review of the literature, the effects of CIT alone, or combined with exercise, on muscle mass and muscle strength and physical performance among older adults.
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Record Fields
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- Meta Analysis Id
- 1894
- Evidence Id
- 10452
- Core Evidence Id
- 10452
- Source Meta Analysis Id
- 1834
- Herb2 Meta Analysis Id
- HBMA001834
- Crd Id
- CRD42019145681
- Title
- Effects of citrulline alone or combined with exercise on muscle mass, muscle strength and physical performance among older adults: a systematic review (Protocol)
- Review Question
- Objective: To summarize, with a systematic review of the literature, the effects of CIT alone, or combined with exercise, on muscle mass and muscle strength and physical performance among older adults.
- Study Type Included
- Studies to be included will be the Randomized, Controlled, Trials (RCTs), which have assessed the effects of CIT alone, or combined with exercise, on muscle mass and muscle strength and physical performance among older adults. The detailed eligibility criteria are as follow: Eligibility criteria Inclusion criteria Topic: the effects of Citrulline alone or combined with exercise on muscle mass and muscle function among older adult Participants: older adults (human >65 years) Design: Randomized controlled trials Outcome: Muscle mass and/or muscle function Date: no limit Exclusion criteria Language: Non-English language publication
- Condition Being Studied
- It has been suggested that citrulline (CIT; a non-proteinogenic amino acid) supplementation can influence muscle and fat metabolism in animal and human models. Regarding human effects, studies showed interesting and potential health benefits in non-healthy older adults. Figueroa et al showed that 8-weeks of CIT (6g/d) combined with vibration training lead to a greater increase in leg lean body mass index than exercise training or CIT alone without affecting fat mass in hypertensive obese postmenopausal women. In addition, Bouillane et al. observed in malnourished older patient that only women increased lean mass and Appendicular Skeletal Muscle Mass, and decreased fat mass after a CIT supplementation of 3 weeks (10g/d). Finally, Ashley et al. noted that CIT supplementation could improve the rate of rise in VO2 at exercise onset in men. Finally, our team recently showed that HIIT+CIT represent an attractive strategy to delay or prevent loss of autonomy in dynapenic-obese older adults. However, because of the heterogeneity of the randomized controlled trials performed on this topic, the effects of Citrulline on muscle muscle mass, muscle strength and physical performance are not clear. We then sought to re-evaluate these aspects by conducting a systematic review.
- Participant
- Older adults (aged 65 years or older), with no particular consideration about age, ethnicity, gender or country of origin.
- Animal
- Human Disease Modelled
- Intervention
- Citrulline supplementation with or without exercise
- Comparator Control
- Placebo or no change in lifestyle
- Main Outcome
- The main outcome to be considered for this systematic review is muscle mass, assessed by DXA or BIA. Measures of effect The outcomes will be measured before and after the intervention.
- Outcome Measure
- Additional Outcome
- The secondary outcomes to be considered for this systematic review are muscle strength (assessed using portable dynamometer) and physical performance (assessed using validated test such as walking speed, SPPB test). Measures of effect The outcomes will be measured before and after the intervention.
- Study Method
- Systematic review
- Keyword
- Citrulline; Exercise; Humans; Muscle Strength
- Contact
- Mylène Aubertin-Leheudre [email protected]
- Organisational Affiliation
- Université du Québec à Montréal (UQAM)
- Funding Source
- Fanny Buckinx received a post-doctoral fellowship grant from CIHR and FRQS. Mylene Aubertin-Leheudre is supported by FRQS (Junior 2)
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Canada
- Review Stage
- Review Ongoing
- First Submission Date
- 2019-08-02
- Registration Date
- 2019-11-12
- Anticipated Start Date
- 2019-07-25
- Anticipated Completion Date
- 2019-09-30
- Title Cn
- 瓜氨酸单用或联合运动对老年人肌肉质量、肌力和身体功能的影响：系统评价（方案）
- Title En
- Effects of citrulline alone or combined with exercise on muscle mass, muscle strength and physical performance among older adults: a systematic review (Protocol)
- Bilingual Status
- complete