Meta AnalysisID 1847

牙科用钴铬合金的毒理学风险：系统评价

CRD42020178190

What is the biocompatibility in humans of cobalt-chromium alloys used in dentistry? PICO Population/Problem Humans, Human cells Intervention/Exposure Cobalt-Chromium alloys used in a dental application <b

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Meta Analysis Id: 1847
Evidence Id: 10405
Core Evidence Id: 10405
Source Meta Analysis Id: 1788
Herb2 Meta Analysis Id: HBMA001788
Crd Id: CRD42020178190
Title: Toxicological risks of the cobalt-chromium alloys used in dentistry, systematic review.
Review Question: What is the biocompatibility in humans of cobalt-chromium alloys used in dentistry? PICO Population/Problem Humans, Human cells Intervention/Exposure Cobalt-Chromium alloys used in a dental application Comparison N/A Outcome o Cytotoxicity o Sensitization o Irritation or Intracutaneous Reactivity o Acute Systemic Toxicity o Subacute/Subchronic Toxicity o Genotoxicity o Histology
Study Type Included: Included studies: original research articles involving human studies or in vitro studies with human samples. Excluded studies: any non-peer-reviewed article, conference proceedings, editorial, books, theses.
Condition Being Studied: Dentistry. Health effects of metals used for dental applications.
Participant: Inclusion: all case reports and studies involving patients treated with fixed or removable prosthetic or orthodontic constructions containing Cobalt-Chromium alloy, or in vitro studies with human samples and Co-Cr dental alloy. Exclusions: Studies involving to non-dental procedures (such as orthopaedic, valvular, breast or limb prosthesis).
Animal
Human Disease Modelled
Intervention: Cobalt-chromium (Co-Cr) alloys have been used in dentistry for a long period by now because of its mechanical properties and for economic reasons but there have not been many studies focusing on its biological impacts in dentistry. Interventions including all types of dental treatment by using CoCr dental alloy (prosthodontic, orthodontic). Exposures: all negative impacts of Cobalt or Chromium as allergy, sensitisation, irritation, cytotoxicity, genotoxicity or confirmation in the absence of adverse effects.
Comparator Control: All studies meeting the inclusion criteria will be included. If studies include a control group results will be compared to those of the intervention group.
Main Outcome: Primary outcome: evaluation of the safety of the metal alloy which is widely used in dentistry. Measures of effect relative riks reported.
Outcome Measure
Additional Outcome: Additional outcome: regarding the ongoing metallic Cobalt reclassification to CMR IB substance by the Agency of EU, the use of medical CoCr alloys is put to doubt, with this review we would like to systematize knowledge about CoCr safety and that would be useful for all dental community as it is the responsibility of the dentist to select the most appropriate materials to be used. Measures of effect the dentist could more evaluate the risk or safety of CoCr dental alloy and explain to this patient why he thinks it's safe/not safe to put this alloy to the mouth even if Co is classified as cancerogenic.
Study Method: Systematic review
Keyword: Humans
Contact: Alina Vaicelyte [email protected]
Organisational Affiliation: Laboratoire des Multimatériaux et Interfaces (UMR CNRS 5615), University of Lyon 1 http://www.ingenierie-at-lyon.org/en/laboratoire/lmi-multi-materials-and-interfaces/
Funding Source
Other Selection Criteria
Final Publication
Same Topic Review
Published Protocol
Review Type
Language: English
Country: France
Review Stage: Review Ongoing
First Submission Date: 2020-06-30
Registration Date: 2020-07-31
Anticipated Start Date: 2020-04-03
Anticipated Completion Date: 2020-08-01
Title Cn: 牙科用钴铬合金的毒理学风险：系统评价
Title En: Toxicological risks of the cobalt-chromium alloys used in dentistry, systematic review.
Bilingual Status: complete