Meta AnalysisID 1840
胆碱与儿童神经发育结局：一项系统评价和Meta分析
CRD42018115377
1. Does maternal plasma choline level during pregnancy or lactation relate to neurodevelopment in offspring? Further, is there a trimester wise difference in the strength of association? 2. Does maternal choline supplem
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Record Fields
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- Meta Analysis Id
- 1840
- Evidence Id
- 10398
- Core Evidence Id
- 10398
- Source Meta Analysis Id
- 1782
- Herb2 Meta Analysis Id
- HBMA001782
- Crd Id
- CRD42018115377
- Title
- Choline and neurodevelopmental outcomes in children: a systematic review and meta analysis
- Review Question
- 1. Does maternal plasma choline level during pregnancy or lactation relate to neurodevelopment in offspring? Further, is there a trimester wise difference in the strength of association? 2. Does maternal choline supplementation during pregnancy and/or lactation affect long term neurodevelopmental outcomes in their children? 3. Does plasma choline level during infancy relate to neurodevelopmental outcomes? 4. Does choline supplementation during infancy relate to neurodevelopmental outcomes?
- Study Type Included
- Observational and randomized controlled trials (RCTs) will be included. Synthesis of observational studies will be done to estimate the association of choline levels with neurodevelopmental outcomes. RCTs will be pooled to provide evidence on the effect of choline supplementation on neurodevelopmental outcomes. Inclusion criteria • Studies exploring the association of plasma choline level or supplementation with choline in pregnant women, lactating women and in children aged under 10 years on neurodevelopmental outcomes in the children • Original research, either cross sectional, cohort or randomized controlled trial (RCT) • Conducted in apparently healthy human subjects Exclusion criteria • Research done in high risk mothers and/or children • RCTs where mothers or infants receive supplementation of choline along with “other nutrients” known to affect neurodevelopment while the control group does not receive “other nutrients”, • Outcomes assessed in adolescent age group (10-18 years) or in adults, • Studies done in animal models, • Systematic reviews,
- Condition Being Studied
- Choline is essential for the formation of phospholipids and the neurotransmitter acetylcholine (ACh) [1]. It is therefore important for structural and cell signalling roles. It also functions as a methyl donor and is crucial for DNA regulation and repair as well as protein function and intermediary metabolism [2]. Evidence from animal studies suggests that choline supplementation improves cognitive and neurological function [3-4]. Our understanding on the role of choline on neurodevelopment in children is limited. The proposed review aims to synthesize available human studies on this aspect, in order to provide useful direction to future research. 1. Zeisel SH, da Costa KA. Choline: an essential nutrient for public health. Nutr Rev. 2009;67(11):615-23. 2. Niculescu MD, Zeisel SH. Diet, methyl donors and DNA methylation: interactions between dietary folate, methionine and choline. J Nutr. 2002;132(8 Suppl):2333S-2335S. 3. Tabassum S, Haider S, Ahmad S, et al. Chronic choline supplementation improves cognitive and motor performance via modulating oxidative and neurochemical status in rats. Pharmacol Biochem Behav. 2017;159:90-99 4. Cheng RK, MacDonald CJ, Williams CL, et al. Prenatal choline supplementation alters the timing, emotion, and memory performance (TEMP) of adult male and female rats as indexed by differential reinforcement of low-rate schedule behavior. Learn Mem. 2008; 15(3): 153–62.
- Participant
- Studies will be included if they explore the association of plasma choline level or supplementation with choline in pregnant women/lactating women/ in children aged under 10 years on neurodevelopmental outcomes. Therefore, the population of interest for our proposed review will be Pregnant women, in any trimester Lactating women Infants and children aged <10 years
- Animal
- Human Disease Modelled
- Intervention
- Plasma choline levels and/or supplementation with choline
- Comparator Control
- No supplementation with choline (specific to pooling of findings from RCTs)
- Main Outcome
- Primary outcomes In this review, we are primarily interested in the effect of the intervention/exposure on neurodevelopmental outcomes i.e. cognitive, motor and language performance along with higher executive functions in children aged under 10 years. Secondary outcome(s) None
- Outcome Measure
- Additional Outcome
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Child; Child Development; Choline; Humans
- Contact
- Ravi Prakash Upadhyay [email protected]
- Organisational Affiliation
- Centre for Health Research and Development, Society for Applied Studies
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- India, Norway
- Review Stage
- Review Ongoing
- First Submission Date
- 2018-10-31
- Registration Date
- 2018-11-20
- Anticipated Start Date
- 2018-11-01
- Anticipated Completion Date
- 2019-04-30
- Title Cn
- 胆碱与儿童神经发育结局：一项系统评价和Meta分析
- Title En
- Choline and neurodevelopmental outcomes in children: a systematic review and meta analysis
- Bilingual Status
- complete