Meta AnalysisID 1839
胆碱补充对胎儿酒精暴露后代神经、认知和行为结局的影响：一项临床和临床前研究的系统评价
CRD42017080052
Can choline supplementation ameliorate neurological, cognitive or behavioural deficits in offspring resulting from fetal alcohol exposure?
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Record Fields
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- Meta Analysis Id
- 1839
- Evidence Id
- 10397
- Core Evidence Id
- 10397
- Source Meta Analysis Id
- 1781
- Herb2 Meta Analysis Id
- HBMA001781
- Crd Id
- CRD42017080052
- Title
- Effect of choline supplementation on neurological, cognitive and behavioural outcomes in offspring arising from fetal alcohol exposure: a systematic review of clinical and preclinical studies.
- Review Question
- Can choline supplementation ameliorate neurological, cognitive or behavioural deficits in offspring resulting from fetal alcohol exposure?
- Study Type Included
- For clinical studies, randomised controlled trials (RCTs), quasi-RCTs or prospective cohort studies will be included. For preclinical trials, there must be random allocation of animals to treatments, appropriate controls and replication.
- Condition Being Studied
- Neurological, behavioural or cognitive outcomes (all ages).
- Participant
- Studies were required to satisfy the following inclusion/exclusion criteria with respect to participants: (1) children with diagnosed FASD or suspected to have been exposed to moderate to heavy fetal alcohol exposure, with a statement on the diagnostic criteria used for FASD assessment and methods for maternal alcohol consumption assessment; (2) preclinical studies to include any mammal model with alcohol exposure (any route of administration) during pregnancy or during the third trimester-equivalent period in rodents (up to postnatal day 10), with the alcohol concentration and dose to be specified.
- Animal
- Human Disease Modelled
- Intervention
- Choline supplementation may be maternal (during pregnancy and/or lactation) and/or postnatal in offspring (any age); choline dose and route of administration must be specified; choline must be in addition to normal choline intake from the diet; studies using experimentally manipulated, low choline diets were excluded; choline may be given alone or in combination with other micronutrient supplementation but the impact of the choline itself on offspring outcomes must be measurable.
- Comparator Control
- The comparative control group must also have been exposed to alcohol in the same manner as the intervention group. The vehicle for the intervention (or a placebo) must also have been applied to the control group.
- Main Outcome
- Primary outcomes to be assessed in offspring will be cognitive, behavioural, motor, learning/memory and/or neurological outcomes (including molecular control of neurological function). These will be assessed using standardised measures.
- Outcome Measure
- Additional Outcome
- Not applicable.
- Study Method
- Intervention, Pre-clinical review (if the review is primarily pre-clinical please register it as a Pre-clinical review instead)
- Keyword
- Choline; Cognition; Ethanol; Humans
- Contact
- Lisa Akison [email protected]
- Organisational Affiliation
- The University of Queensland
- Funding Source
- Funding provided by the Children's Health Research Centre, The University of Queensland.
- Other Selection Criteria
- Final Publication
- Review published in Alcoholism: Clinical and Experimental Research in June 2018. https://onlinelibrary.wiley.com/doi/10.1111/acer.13817
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Australia
- Review Stage
- Review Completed published
- First Submission Date
- 2017-10-24
- Registration Date
- 2017-12-04
- Anticipated Start Date
- 2017-10-02
- Anticipated Completion Date
- 2017-12-31
- Title Cn
- 胆碱补充对胎儿酒精暴露后代神经、认知和行为结局的影响：一项临床和临床前研究的系统评价
- Title En
- Effect of choline supplementation on neurological, cognitive and behavioural outcomes in offspring arising from fetal alcohol exposure: a systematic review of clinical and preclinical studies.
- Bilingual Status
- complete