Meta AnalysisID 1810

维生素C、维生素E和β-胡萝卜素的摄入量或循环水平与2型糖尿病风险:一项系统评价和Meta分析

CRD42022343482

Are intakes or circulating levels of vitamin C, vitamin E, and beta-carotene associated with insulin secretion/deficiency, insulin resistance, or the incidence of type 2 diabetes?

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Record Fields

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Meta Analysis Id
1810
Evidence Id
10368
Core Evidence Id
10368
Source Meta Analysis Id
1755
Herb2 Meta Analysis Id
HBMA001755
Crd Id
CRD42022343482
Title
Intakes or circulating levels of vitamin C, vitamin E, and beta-carotene and the risk of type 2 diabetes: a systematic review and meta-analysis
Review Question
Are intakes or circulating levels of vitamin C, vitamin E, and beta-carotene associated with insulin secretion/deficiency, insulin resistance, or the incidence of type 2 diabetes?
Study Type Included
We will include observational studies with a cohort, case-cohort, nested-case control, or case-control design, and randomized controlled trials (RCTs). Cross-sectional studies will be excluded.
Condition Being Studied
Type 2 diabetes (T2D), insulin secretion/deficiency, insulin resistance
Participant
The population of interest is individuals at risk of developing type 2 diabetes.
Animal
Human Disease Modelled
Intervention
High dietary intakes, high circulating levels, or high/any supplementation of vitamin C, vitamin E, or beta-carotene, as well as continuous increase of these factors, will be considered as exposures.
Comparator Control
Low dietary intakes, low circulating levels, or low/no supplementation of vitamin C, vitamin E, or beta-carotene will be considered as comparators.
Main Outcome
Type 2 diabetes Measures of effect Risk ratios (RRs), hazard ratios (HRs), odds ratios (ORs)
Outcome Measure
Additional Outcome
Insulin secretion/deficiency Insulin resistance Measures of effect Risk ratios (RRs), hazard ratios (HRs), odds ratios (ORs), mean differences (MDs), standardized mean differences (SMDs)
Study Method
Meta-analysis, Systematic review
Keyword
Ascorbic Acid; Diabetes Mellitus, Type 2; Humans; Vitamin E; beta Carotene
Contact
Anna-Maria Lampousi [email protected]
Organisational Affiliation
Karolinska Institutet
Funding Source
Swedish Research Council, Research Council for Health, Working Life and Welfare, Novo Nordisk Foundation, and the Swedish Diabetes Foundation
Other Selection Criteria
Final Publication
Same Topic Review
Published Protocol
Review Type
Language
English
Country
Sweden
Review Stage
Review Ongoing
First Submission Date
2022-06-30
Registration Date
2022-07-11
Anticipated Start Date
2022-07-15
Anticipated Completion Date
2023-02-15
Title Cn
维生素C、维生素E和β-胡萝卜素的摄入量或循环水平与2型糖尿病风险:一项系统评价和Meta分析
Title En
Intakes or circulating levels of vitamin C, vitamin E, and beta-carotene and the risk of type 2 diabetes: a systematic review and meta-analysis
Bilingual Status
complete