Meta AnalysisID 1808
补充类胡萝卜素对2型糖尿病和血糖谱的影响
CRD42021285084
The promising effect of fruits and vegetables could be partly attributed to their antioxidant constituents. Among the bioactive fruits and vegetable components, special attention is given to carotenoids for their antioxi
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Record Fields
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- Meta Analysis Id
- 1808
- Evidence Id
- 10366
- Core Evidence Id
- 10366
- Source Meta Analysis Id
- 1749
- Herb2 Meta Analysis Id
- HBMA001749
- Crd Id
- CRD42021285084
- Title
- Effect of carotenoids supplementation on type 2 diabetes and glycemic profile
- Review Question
- The promising effect of fruits and vegetables could be partly attributed to their antioxidant constituents. Among the bioactive fruits and vegetable components, special attention is given to carotenoids for their antioxidant, anti-inflammatory, gene expression-modulating properties and their potential for preventing degenerative diseases such as atherosclerosis, cancer, and diabetic complications. Decreased serum carotenoids levels have been also seen in diabetic people in comparison to healthy people. So, carotenoids are currently marketed as a health supplement and are well-known for their antioxidant capacity. However, a few lines of clinical evidence supporting its antidiabetic role and results are conflicting. So, we will perform a systematic review and meta-analysis of clinical studies to investigate the effect of carotenoids on glycemic disorders and diabetes and to evaluate the effects of carotenoids on glycemic parameters, as well.
- Study Type Included
- We will include randomized clinical trials to assess the beneficial effects of the carotenoids treatment on serum/plasma glucose levels or glycemic parameters (including FBG, HgA1c, HOMA-IR, IR).
- Condition Being Studied
- Diabetes mellitus (DM) is a chronic metabolic disorder that results from defects in insulin secretion, insulin signaling, or both, and it is characterized by hyperglycemia and the consequent abnormalities in carbohydrate, lipid, and protein metabolism. Because of uncontrolled hyperglycemia and its consequent complications, DM is currently one of the main leading causes of death.
- Participant
- Inclusion: All adult populations (healthy or unhealthy) Exclusion: Adolescents (under 18 years of age)
- Animal
- Human Disease Modelled
- Intervention
- Population-level carotenoids control interventions are defined as those applied to assess the effect of carotenoids as supplementation with the aim of changing the serum/plasma glucose levels or glycemic parameters (including FBG, HgA1c, HOMA-IR, IR) in the adult population.
- Comparator Control
- We will include all eligible papers if they reported the effect of carotenoids supplementation, not along with other nutrients (multi-antioxidant supplement), compared with the control group and report the effect of carotenoids supplementation at the end of treatment by providing mean (±SD) for glycaemic profiles or relevant data. Intervention: Carotenoids supplementation alone Placebo: A group of the same participants without Carotenoids supplementation
- Main Outcome
- Change in glycemic profiles from baseline to the last available follow-up, measured using the serum/plasma glucose levels or glycemic parameters (including FBG, HgA1c, HOMA-IR, IR). Measures of effect the effect of carotenoids supplementation at the end of treatment will be measured by providing mean (±SD) for glycaemic profiles or relevant data.
- Outcome Measure
- Additional Outcome
- Change in ncidence of diabetes by carotenoids supplementation Measures of effect The additional outcomes will be measured by odds ratios, risk differences.
- Study Method
- Prospective meta-analysis (PMA), Systematic review
- Keyword
- Blood Glucose; Carotenoids; Diabetes Mellitus, Type 2; Dietary Supplements; Glycated Hemoglobin A; Humans
- Contact
- Nafiseh Shokri-mashhadi [email protected]
- Organisational Affiliation
- Isfahan University of medical science AND German Diabetes Center (DDZ) WWW.mui.ac.ir
- Funding Source
- Isfahan University of medical science
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Iran
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-10-13
- Registration Date
- 2021-11-13
- Anticipated Start Date
- 2021-10-13
- Anticipated Completion Date
- 2022-02-01
- Title Cn
- 补充类胡萝卜素对2型糖尿病和血糖谱的影响
- Title En
- Effect of carotenoids supplementation on type 2 diabetes and glycemic profile
- Bilingual Status
- complete