Meta AnalysisID 1804
维生素C、维生素E、β-胡萝卜素与帕金森病风险：观察性研究的系统评价和剂量反应Meta分析
CRD42022318388
Is there any association between daily intake of vitamin C, vitamin E, beta carotene and the risk of Parkinson's disease and its dose-response relationship? The type of study selected is observational
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Record Fields
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- Meta Analysis Id
- 1804
- Evidence Id
- 10362
- Core Evidence Id
- 10362
- Source Meta Analysis Id
- 1751
- Herb2 Meta Analysis Id
- HBMA001751
- Crd Id
- CRD42022318388
- Title
- Vitamin C, Vitamin E, β-carotene and risk of Parkinson’s disease: a systematic review and dose-response meta-analysis of observational studies
- Review Question
- Is there any association between daily intake of vitamin C, vitamin E, beta carotene and the risk of Parkinson's disease and its dose-response relationship? The type of study selected is observational
- Study Type Included
- Observational study such as：Case-control; Cohort studies
- Condition Being Studied
- Recent evidence suggests that oxidative stress plays an important role in the pathogenesis of the disease. Vitamin C, vitamin E and beta carotene have always been the research focus of antioxidants. However, data on the relationship between dietary and supplement intake of vitamin C, vitamin E and beta carotene and the risk of Parkinson's disease are contradictory. Therefore, we will conduct a systematic review and meta-analysis of observational studies to assess the association between the intake of these three substances and the risk of Parkinson's disease and its dose-response relationship. Our research institution is located in a first-class university in China with strong faculty. Our team has published many systematic reviews and meta-analyses in international journals
- Participant
- The included participants should be at least 18 years old and have no Parkinson's disease patients with other neurological diseases. It can also measure the specific doses of vitamin C, vitamin E and beta carotene
- Animal
- Human Disease Modelled
- Intervention
- Observational study reporting dietary and supplement intake of vitamin C, vitamin E, and beta-carotene as exposure
- Comparator Control
- Subjects in the lowest categories of dietary intake of the following antioxidants: vitamin C, vitamin E and beta-carotene
- Main Outcome
- The incidence rate of Parkinson’s disease Measures of effect Risk ratios (RRs), or Hazard ratios (HRs), odds ratio (OR) and their 95% confidence intervals
- Outcome Measure
- Additional Outcome
- None Measures of effect Not applicable
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Ascorbic Acid; Humans; Parkinson Disease; Vitamin A; Vitamin E; beta Carotene
- Contact
- Fang Niu [email protected]
- Organisational Affiliation
- Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing, 210009, Jiangsu Province, China
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-03-17
- Registration Date
- 2022-04-17
- Anticipated Start Date
- 2022-03-17
- Anticipated Completion Date
- 2022-05-17
- Title Cn
- 维生素C、维生素E、β-胡萝卜素与帕金森病风险：观察性研究的系统评价和剂量反应Meta分析
- Title En
- Vitamin C, Vitamin E, β-carotene and risk of Parkinson’s disease: a systematic review and dose-response meta-analysis of observational studies
- Bilingual Status
- complete