Meta AnalysisID 1758
17-α-羟孕酮己酸酯用于维持性安胎：随机试验的Meta分析
CRD42014013473
The objective of this meta-analysis is to evaluate the efficacy of maintenance tocolysis with 17-alpha-hydroxyprogesterone caproate (17P) compared to placebo or no treatment in singleton gestations with arrested preterm
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 1758
- Evidence Id
- 10316
- Core Evidence Id
- 10316
- Source Meta Analysis Id
- 1705
- Herb2 Meta Analysis Id
- HBMA001705
- Crd Id
- CRD42014013473
- Title
- 17-alpha-hydroxyprogesterone caproate for maintenance tocolysis: a meta-analysis of randomized trials
- Review Question
- The objective of this meta-analysis is to evaluate the efficacy of maintenance tocolysis with 17-alpha-hydroxyprogesterone caproate (17P) compared to placebo or no treatment in singleton gestations with arrested preterm labor in a meta-analysis of randomized trials.
- Study Type Included
- We included randomized trials of singleton gestations that had arrested preterm labor and then were randomized to maintenance tocolysis treatment with either 17P or control (either placebo or no treatment). All published randomized studies on progesterone tocolysis were carefully reviewed.
- Condition Being Studied
- Preterm birth (PTB), defined as any birth before 37 weeks, is responsible for most of the neonatal morbidity and mortality in the United States and 35% of all U.S. healthcare spending on infants. Globally, about 28% of the 4 million annual neonatal deaths are directly attributable to PTB. Preterm labor (PTL) is the final pathway for about half of all PTB. Tocolytic agents include a wide range of drugs that can slow or stop labor contractions delaying births caused by PTL. Primary tocolysis is tocolysis given on initial presentation of women with PTL. In most of these women, PTL stops. Their risk of PTB remains high and so some have advocated use of maintenance tocolysis, i.e. tocolysis after arrested PTL. So far, no maintenance tocolytic has been shown to be beneficial in preventing PTB. Recently, progesterone has been used successfully for prevention of preterm birth. The objective of this meta-analysis was to evaluate the efficacy of maintenance tocolysis with 17-alpha-hydroxyprogesterone caproate (17P) compared to placebo or no treatment in singleton gestations with arrested preterm labor in a meta-analysis of randomized trials.
- Participant
- We included randomized trials of singleton gestations that had arrested preterm labor and then were randomized to maintenance tocolysis treatment with either 17P or control (either placebo or no treatment). All published randomized studies on progesterone tocolysis were carefully reviewed. Exclusion criteria included quasi-randomized trials, maintenance tocolysis in women with preterm premature rupture of membrane (PPROM) and maintenance tocolysis with vaginal progesterone.
- Animal
- Human Disease Modelled
- Intervention
- The objective of this meta-analysis is to evaluate the efficacy of maintenance tocolysis with 17-alpha-hydroxyprogesterone caproate (17P) compared to placebo or no treatment. Most studies used 17P 250mg IM weekly. Four out of 5 used no treatment as control.
- Comparator Control
- Four out of 5 used no treatment as control, while one used placebo.
- Main Outcome
- The primary outcome included PTB <37 weeks
- Outcome Measure
- Additional Outcome
- Secondary outcomes included PTB<34weeks, gestational of delivery, latency, sPTB<37 weeks, sPTB<34 weeks, birth weight, neonatal death, admission in neonatal intensive care unit (NICU), neonatal respiratory distress syndrome (RDS), bronchopulmonary dysplasia (BPD), intraventricular hemorrhage (IVH), necrotizing enterocolitis (NEC), and neonatal sepsis.
- Study Method
- Keyword
- 17-alpha-Hydroxyprogesterone; Caproates; Female; Humans; Hydroxyprogesterones; Pregnancy; Tocolysis
- Contact
- Dr Saccone [email protected]
- Organisational Affiliation
- Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Thomas Jefferson University Hospital, Philadelphia
- Funding Source
- No funding sources/sponsor
- Other Selection Criteria
- Final Publication
- Saccone G, Suhag A, Berghella V. 17-alpha-hydroxyprogesterone caproate for maintenance tocolysis: a systematic review and meta-analysis of randomized trials. Am J Obstet Gynecol. 2015 Feb 4. pii: S0002-9378(15)00110-6. doi: 10.1016/j.ajog.2015.01.054. [Epub ahead of print]
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- United States of America
- Review Stage
- Review Completed published
- First Submission Date
- Registration Date
- 2014-09-03
- Anticipated Start Date
- 2014-08-01
- Anticipated Completion Date
- 2014-10-13
- Title Cn
- 17-α-羟孕酮己酸酯用于维持性安胎：随机试验的Meta分析
- Title En
- 17-alpha-hydroxyprogesterone caproate for maintenance tocolysis: a meta-analysis of randomized trials
- Bilingual Status
- complete