Meta AnalysisID 161
柴胡方剂治疗抗结核药物性肝损伤：一项系统评价与Meta分析
CRD42021262540
The aim of this meta-analysis of randomized controlled trials is to evaluate the efficacy and effectiveness of BC formula for the antituberculosis drug-induced hepatotoxicity.
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 161
- Evidence Id
- 8719
- Core Evidence Id
- 8719
- Source Meta Analysis Id
- 146
- Herb2 Meta Analysis Id
- HBMA000146
- Crd Id
- CRD42021262540
- Title
- Bupleurum chinense herbal formula for the antituberculosis drug-induced hepatotoxicity : A systematic review and meta-analysis
- Review Question
- The aim of this meta-analysis of randomized controlled trials is to evaluate the efficacy and effectiveness of BC formula for the antituberculosis drug-induced hepatotoxicity.
- Study Type Included
- Randomized controlled trials (RCTs) will be included.
- Condition Being Studied
- Tuberculosis (TB), as a global concern, seriously affects people's health. The WHO global tuberculosis report 2020 estimates that in 2019 10.0 million people fell ill with TB. Most of the first-line drugs used in the treatment of TB have potentially hepatotoxic effects. The standard short-course chemotherapy is an effective way to control TB, which includes a combination treatment of isoniazid , rifampicin, pyrazinamide, and ethambutol. Anti-TB chemotherapy often has a long course of treatment, and the combined use of multiple anti-TB medications has a heavier burden on the liver, which easily leads to patients being forced to stop treatment. Antituberculosis drug hepatotoxicity (ATDH), which makes it difficult for patients to adhere to the entire course of chemotherapy, is the most serious adverse effect of anti-tuberculosis therapy. As an ancient therapeutic method, Bupleurum chinense (BC, Radix Bupleuri) herbal formula has been used for thousands of years in China. Since the 1990s, there have been many clinical reports of BC formula for ATDH, and the curative effect is remarkable. However, There is a lack of systematic review on the BC formula for ATDH.
- Participant
- Inclusion criteria: Patients with liver injury after taking antituberculosis drugs. Gender and age are not limited. Exclusion criteria: Patients with other causes of liver injury or with underlying liver disease. Clinical data were lost or incomplete.
- Animal
- Human Disease Modelled
- Intervention
- Inclusion criteria: Patients were intervened with Bupleurum chinense (BC, Radix Bupleuri) herbal formula for intervention. Exclusion criteria: Patients were intervened by other ways except BC formula. (e.g. silybin, reduced glutathione)
- Comparator Control
- Inclusion criteria: Patients were intervened by other ways except BC formula. (e.g. silybin, reduced glutathione) Or stop using antituberculosis drugs, do not implement liver protection treatment. Exclusion criteria: Patients were intervened with Bupleurum chinense (BC, Radix Bupleuri) herbal formula for intervention.
- Main Outcome
- The total effective rate. Measures of effect RR
- Outcome Measure
- Additional Outcome
- ALT(alanine aminotransferase), AST (aspartate aminotransferase) and TBil (total bilirubin). Measures of effect MD
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Antitubercular Agents; Bupleurum; Bupleurum falcatum; Chemical and Drug Induced Liver Injury; Humans; Plants, Medicinal
- Contact
- ZHENG SHI [email protected]
- Organisational Affiliation
- Nanjing University of Chinese Medicine, Inst Literature Chinese Med http://yswx.njucm.edu.cn/
- Funding Source
- National Natural Science Foundation of China (NSFC) Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> 81904322
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Completed not published
- First Submission Date
- 2021-06-23
- Registration Date
- 2021-07-25
- Anticipated Start Date
- 2021-06-22
- Anticipated Completion Date
- 2021-07-23
- Title Cn
- 柴胡方剂治疗抗结核药物性肝损伤：一项系统评价与Meta分析
- Title En
- Bupleurum chinense herbal formula for the antituberculosis drug-induced hepatotoxicity : A systematic review and meta-analysis
- Bilingual Status
- complete