Meta AnalysisID 1595
咖啡酸及其衍生物对不同黑色素瘤细胞系的潜在治疗作用：一项系统评价方案
CRD42021215920
Does caffeic acid and its derivatives have potential therapeutic effects on in vivo animal models and/or in vitro models melanoma? Context and rationale Cutaneous melanoma is a skin neoplasia with origin in melanocyte ce
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Record Fields
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- Meta Analysis Id
- 1595
- Evidence Id
- 10153
- Core Evidence Id
- 10153
- Source Meta Analysis Id
- 1550
- Herb2 Meta Analysis Id
- HBMA001550
- Crd Id
- CRD42021215920
- Title
- Caffeic acid and its derivatives potential therapeutics effects on different melanoma cell lines: a project to a sistematic review
- Review Question
- Does caffeic acid and its derivatives have potential therapeutic effects on in vivo animal models and/or in vitro models melanoma? Context and rationale Cutaneous melanoma is a skin neoplasia with origin in melanocyte cells that is very metastatic. Although it's a less common skin cancer, it's responsible for a lot of deaths globally every year, being the principal cause of death by skin neoplasias. Thus, treatments to this type of skin cancer is being researched world wide, and, as such, there has been an effort to elucidate the role of caffeic acid and its derivatives, that are organic compounds commonly found on many plants with potential anti-oxidant, anti-inflammatory and anti-neoplastic effects. Because of the high metastatic and mortality rate of cutaneous melanoma, clinical research on caffeic acid (and its derivatives) would be important if the pre-clinical studies demonstrate benefits of its uses on melanoma cells. Knowing this, the best way to show if caffeic acid is relevant and safe for initiation of clinical tests would be a Systematic Review on the studies of in vitro and in vivo efficacy and security use of caffeic acid and derivatives on melanoma cells.
- Study Type Included
- Inclusion criteria: In vivo and/or in vitro experimental studies Exclusion criteria: Studies with no interventions and/or no controls; clinical studies; observational studies; descriptive only studies; retrospective studies;
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: Any type of animal with melanoma Exclusion criteria: Animals with other neoplasias and without melanoma / clinical studies
- Human Disease Modelled
- Cutaneous melanoma is a tumor that had been growing in the last decades. It has the higher mortality rates among skin cancers, and it's prevalent in caucasian population.
- Intervention
- Inclusion criteria: Use of caffeic acid and derivatives (Caffeic acid phenethyl ester, chlorogenic acid, rosmarinic acid and etc) at any dosage, timing and frequency, via subcutaneous, endovenous, oral or intramuscular with any or none vehicle. Exclusion criteria: Use of any compound that don't derivates from caffeic acid.
- Comparator Control
- Inclusion criteria: All In vivo or in vitro models treated with already recognized interventions for melanoma or untreated models. Exclusion criteria: Comparison with in vivo or in vitro models treated with non recognized interventions.
- Main Outcome
- Outcome Measure
- Inclusion criteria: Tumor area; tumor volume; celular viability (%) Exclusion criteria: Only color; only weight.
- Additional Outcome
- Study Method
- Keyword
- Animals; Caffeic Acids; Cell Line; Melanoma; caffeic acid
- Contact
- Margarete Dulce Bagatini [email protected]
- Organisational Affiliation
- Federal University of Southern Frontier
- Funding Source
- There is no funding sources/sponsors Grant number(s) 0
- Other Selection Criteria
- Inclusion criteria: all publication dates; Exclusion criteria: other language than portuguese, spanish or english; gray literature (included but not restringed to the following: technical normatives, no editorial control, abstracts and etc); clinical phases studies;
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Pre-clinical animal intervention review
- Language
- Portuguese-Brazil
- Country
- Brazil
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-10-23
- Registration Date
- 2021-02-04
- Anticipated Start Date
- 2020-07-05
- Anticipated Completion Date
- 2021-07-05
- Title Cn
- 咖啡酸及其衍生物对不同黑色素瘤细胞系的潜在治疗作用：一项系统评价方案
- Title En
- Caffeic acid and its derivatives potential therapeutics effects on different melanoma cell lines: a project to a sistematic review
- Bilingual Status
- complete