Meta AnalysisID 1593
职业性镉暴露与肾毒性生物标志物的关联：系统评价与Meta分析
CRD42022380923
How the occupational Cd-exposure associated with different categories of nephrotoxic biomarkers?
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 1593
- Evidence Id
- 10151
- Core Evidence Id
- 10151
- Source Meta Analysis Id
- 1548
- Herb2 Meta Analysis Id
- HBMA001548
- Crd Id
- CRD42022380923
- Title
- Association between occupational cadmium exposure and nephrotoxic biomarkers: A systematic review and Meta analysis.
- Review Question
- How the occupational Cd-exposure associated with different categories of nephrotoxic biomarkers?
- Study Type Included
- Observational studies were included. (1) participants <18 years of age; 2) case reports, reviews, letters to editors, editorials, and methodological papers; 3) duplicated data and incomplete information studies; 4) Data cannot be converted into the outcome indicators, and 5) animal experiments and basic research were excluded.
- Condition Being Studied
- Cadmium-exposure results in chronic renal failure (CRF), tubular nephropathy, and a reduction in glomerular filtration rate (GFR). The crucial steps such as oxidative stress, DNA damage, cell cycle arrest, and cell death cause renal dysfunction (Zhang et al., 2021). The renal markers like urea, Serum creatinine (SCr), and microalbumin were significantly increased in Cd exposed workers (Bot et al., 2020), however, these biomarkers are insensitive and inadequately specific (Pocsi et al., 2022). β2-microglobulin (β2M) and N-acetyl-B-D-Glucosaminidase (NAG) are found sensitive biomarkers for renal injury in Cd-exposure (Qing et al., 2021) and the level of β2M is unstable in urine at PH less than 7.0 (Pocsi et al., 2022). Kidney injury molecule1(KIM1) and α-glutathione S-transferase (α-GST) are two novel biomarkers proposed for Cd-induced nephrotoxicity (Prozialeck and Edwards, 2010). Pennemans et al. (2020) reported a positive association between KIM1 and urinary cadmium in elderly people with long-term and low-dose cadmium exposure. The other classical markers like α1-MG, β2M, Blood urea nitrogen, urinary proteins, and microalbumin do not show an association. Present systematic review and meta-analysis will address the above- mentioned limitations, by pooling individual nephrotoxic biomarkers in occupational Cd-exposure. The review aimed at investigating different categories of nephrotoxicity biomarkers in occupational Cd-exposure.
- Participant
- Occupational Cd-exposed workers and unexposed subjects/ or controls
- Animal
- Human Disease Modelled
- Intervention
- Cd-exposure in terms of Blood or urine cadmium with different nephrotoxic markers. Biomarkers of Cd-induced nephrotoxicity includes serum creatinine (SCr), blood urea nitrogen (BUN), urinary albumin (UALB), β2-microglublin (β2M), retinal binding protein (RBP), N-acetyl-β-D-Glucosaminidase (NAG) and its isoenzymes (NAG-A and NAG-B), kidney injury molecule-1 (KIM-1), alpha 1 microglobulin (α1-MG), and alanine amino peptidase (AAP).
- Comparator Control
- Control or unexposed subjects
- Main Outcome
- Primary: Nephrotoxic biomarkers All the parameters to be continuous variables and mean difference/standardized mean difference will be pooled Measures of effect Risk differences between Case and controls
- Outcome Measure
- Additional Outcome
- Not applicable
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Biomarkers; Cadmium; Humans; Metallothionein; Occupational Exposure
- Contact
- Ravibabu Kalahasthi [email protected]
- Organisational Affiliation
- ICMR - Regional occupational Health center ( Southern) www.nioh.org
- Funding Source
- None Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> None
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Not applicable
- Published Protocol
- Review Type
- Language
- English
- Country
- India
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-12-02
- Registration Date
- 2022-12-13
- Anticipated Start Date
- 2022-12-02
- Anticipated Completion Date
- 2023-06-30
- Title Cn
- 职业性镉暴露与肾毒性生物标志物的关联：系统评价与Meta分析
- Title En
- Association between occupational cadmium exposure and nephrotoxic biomarkers: A systematic review and Meta analysis.
- Bilingual Status
- complete