Meta AnalysisID 1591
母亲镉水平与子痫前期的相关性
CRD42022361291
How does exposure cadmium affect maternal risk of preeclampsia?
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Record Fields
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- Meta Analysis Id
- 1591
- Evidence Id
- 10149
- Core Evidence Id
- 10149
- Source Meta Analysis Id
- 1546
- Herb2 Meta Analysis Id
- HBMA001546
- Crd Id
- CRD42022361291
- Title
- Correlation between Maternal Cadmium Levels and Preeclampsia
- Review Question
- How does exposure cadmium affect maternal risk of preeclampsia?
- Study Type Included
- Prospective or retrospective observational studies
- Condition Being Studied
- Preeclampsia complicates around 5% of all pregnancies worldwide. In lower-middle-income countries, the incidence has increased despite some measures taken to prevent this disease. Preeclampsia still accounts for the leading causes of maternal and perinatal morbidity and mortality in the developing world. There are many researches on the risk factors for preeclampsia across different genetic and ethnic backgrounds. However, micronutrients could also have an impact on the risks of developing hypertensive disorders in pregnancy. Cadmium was associated with the inflammatory response in the human body. Dysfunctional inflammation was initially triggered in early pregnancy, which sequentially leads to preeclampsia in some women. In this sense, cadmium levels may implicate the risks of preeclampsia. Researches by far report controversial results on its levels and association with preeclampsia. Therefore, we want to include all the articles available now to draw the conclusion between cadmium levels and preeclampsia.
- Participant
- We included all the studies that focus on pregnant women. Normotensive uncomplicated pregnancies reported in the respective publication were considered as control groups. Published studies were eligible for inclusion if they reported cadmium exposure and in women with or without preeclampsia. Exclusion criteria: PE, cadmium exposure data were not available or could not be extracted from the study groups; no appropriate control group
- Animal
- Human Disease Modelled
- Intervention
- The study group should have accurate data on cadmium exposure.
- Comparator Control
- The control group is the normotensive pregnant women in respective studies with accurate data on cadmium exposure.
- Main Outcome
- The relative risk, severity and onset of preeclampsia.
- Outcome Measure
- Additional Outcome
- pre-term delivery, maternal ICU admission, NICU admission
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Cadmium; Female; Fetal Blood; Humans; Placenta; Pre-Eclampsia; Pregnancy
- Contact
- Chu Li [email protected]
- Organisational Affiliation
- Zhejiang Chinese Medical University
- Funding Source
- Zhejiang Provincial Project for Medical and Health Science (No.2022503241)
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-09-19
- Registration Date
- 2022-09-30
- Anticipated Start Date
- 2022-09-01
- Anticipated Completion Date
- 2022-11-01
- Title Cn
- 母亲镉水平与子痫前期的相关性
- Title En
- Correlation between Maternal Cadmium Levels and Preeclampsia
- Bilingual Status
- complete