Meta AnalysisID 1571
丁苯酞联合奥拉西坦治疗血管性认知障碍的疗效：一项Meta分析
CRD42020210179
The aim of this study was to evaluate the efficacy of butylphthalide combined with oxiracetam in the treatment of vascular cognitive impairment. P：Patients with vascular cognitive impairment I：butylphthalide combined wit
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 1571
- Evidence Id
- 10129
- Core Evidence Id
- 10129
- Source Meta Analysis Id
- 1525
- Herb2 Meta Analysis Id
- HBMA001525
- Crd Id
- CRD42020210179
- Title
- Efficacy of butylphthalide combined with oxiracetam in the treatment of vascular cognitive impairment: a meta analysis
- Review Question
- The aim of this study was to evaluate the efficacy of butylphthalide combined with oxiracetam in the treatment of vascular cognitive impairment. P：Patients with vascular cognitive impairment I：butylphthalide combined with oxiracetam C：butylphthalide only or oxiracetam only or routine therapy O：Efficiency, cognitive and life function, biochemical indicators S：meta analysis
- Study Type Included
- RCT
- Condition Being Studied
- Vascular cognitive impairment is the second most common cause of dementia after Alzheimer's disease. The mechanism of dementia is still unclear. It is easy to combine other types of dementia on the basis of vascular cognitive impairment. Therefore, active prevention of risk factors and the search for effective drug treatment can benefit patients with vascular disease for a long time
- Participant
- Inclusion criteria① The study type was clinical randomized controlled study. ② The subjects were in accordance with the diagnosis of vascular cognitive impairment, including vascular dementia and non dementia cognitive impairment caused by acute cerebrovascular disease. ③ Intervention measures: the observation group was treated with butylphthalide combined with oxiracetam, while the control group was treated with butylphthalide alone or oxiracetam alone or conventional medical treatment. ④ Outcome evaluation indicators: efficacy, cognitive function evaluation, life function evaluation, adverse reactions and biochemical indicators. ⑤ There is no limit to languages. Exclusion criteria① Case reports or reviews. ② There were other types of cognitive impairment. ③ Other organic diseases affect outcome indicators. ④ Articles published repeatedly in the same research center.
- Animal
- Human Disease Modelled
- Intervention
- treated with butylphthalide combined with oxiracetam
- Comparator Control
- butylphthalide alone or oxiracetam alone or conventional medical treatment
- Main Outcome
- Butylphthalide combined with oxiracetam is beneficial to vascular cognitive impairment. Compared with the control group, the combined treatment can reduce adverse reactions and improve cognitive function and life ability. Measures of effect OR, SMD, MD
- Outcome Measure
- Additional Outcome
- NONE Measures of effect odds ratio，mean difference and standardized mean difference
- Study Method
- Meta-analysis, Systematic review
- Keyword
- 3-n-butylphthalide; Benzofurans; Cognitive Dysfunction; Humans; Pyrrolidines; oxiracetam
- Contact
- Zixuan Ying [email protected]
- Organisational Affiliation
- Nanjing medical university No. 300 Guangzhou Road, Nanjing, 210029 China
- Funding Source
- Jiangsu Health Committee Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> BJ18016
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- Chinese-Simplified, English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-09-19
- Registration Date
- 2020-10-20
- Anticipated Start Date
- 2020-08-01
- Anticipated Completion Date
- 2021-01-01
- Title Cn
- 丁苯酞联合奥拉西坦治疗血管性认知障碍的疗效：一项Meta分析
- Title En
- Efficacy of butylphthalide combined with oxiracetam in the treatment of vascular cognitive impairment: a meta analysis
- Bilingual Status
- complete