Meta AnalysisID 157
植物营养素与乳腺癌生存结局：观察性研究的系统评价与Meta分析
CRD42022366097
• Does evidence from observational studies demonstrate an impact of phytonutrients and phytonutrient-containing foods, green tea (Camellia sinensis, L.), Cruciferae-family vegetables and the phytoestrogen-containing plan
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 157
- Evidence Id
- 8715
- Core Evidence Id
- 8715
- Source Meta Analysis Id
- 143
- Herb2 Meta Analysis Id
- HBMA000143
- Crd Id
- CRD42022366097
- Title
- Phytonutrients in breast cancer survival outcomes: a systematic review and meta-analysis of observational studies
- Review Question
- • Does evidence from observational studies demonstrate an impact of phytonutrients and phytonutrient-containing foods, green tea (Camellia sinensis, L.), Cruciferae-family vegetables and the phytoestrogen-containing plants, soybean (Glycine max, L., Merr., Fabaceae family) and flaxseed/linseed (Linum usitatissimum, Linn., Linaceae family), on breast cancer prognosis: recurrence, disease-free survival and overall survival? • Do hormone receptor or molecular subtype, menopausal status, concurrent tamoxifen use or time of exposure impact on these effects? • Is there a dose-effect relationship for each of these exposures? • Do the current data inform about post-diagnostic dietary introduction, as distinct from pre-diagnostic/established intake of the exposures on survival outcomes?
- Study Type Included
- observational or epidemiological studies: retrospective or prospective cohort study/ longitudinal study; observational follow-up from RCTs
- Condition Being Studied
- Breast cancer
- Participant
- People with a history of breast cancer
- Animal
- Human Disease Modelled
- Intervention
- Phytonutrients (bioactive plant-derived compounds) and biomarkers of their intake, and the phytonutrient-containing foods, green tea (Camellia sinensis, L.), Cruciferae-family vegetablesand the phytoestrogen-containing plants, soybean (Glycine max, L., Merr., Fabaceae family) and flaxseed/linseed (Linum usitatissimum, Linn., Linaceae family), administered via oral routes.
- Comparator Control
- lower, or no, intake of the exposure
- Main Outcome
- Recurrence: local, ipsilateral, contralateral, regional, distant recurrence/metastases, new primaries (deaths are censored) Disease-free survival (DFS): the time from randomization to recurrence of tumor or death Mortality: all-cause mortality/overall mortality: including death from any cause Breast cancer-specific mortality: including death due to breast cancer; other deaths are censored distant disease-free survival: including distant recurrence and death from any cause - from time of initial treatment of local disease Measures of effect Hazard ratio (HR) relative risk (RR), or Odds ratio (OR), p-values for trend and interaction
- Outcome Measure
- Additional Outcome
- dose-effect relationship safety Measures of effect cubic splines adverse events will be extracted
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Brassicaceae; Breast Neoplasms; Camellia sinensis; Disease-Free Survival; Female; Flax; Humans; Menopause; Phytochemicals; Phytoestrogens; Soybeans; Tamoxifen; Tea; Vegetables
- Contact
- Margaret VAN DIE [email protected]
- Organisational Affiliation
- NICM, Western Sydney University https://www.westernsydney.edu.au
- Funding Source
- None Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> None
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Australia, Denmark, United States of America
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-10-10
- Registration Date
- 2022-10-20
- Anticipated Start Date
- 2022-10-17
- Anticipated Completion Date
- 2022-12-31
- Title Cn
- 植物营养素与乳腺癌生存结局：观察性研究的系统评价与Meta分析
- Title En
- Phytonutrients in breast cancer survival outcomes: a systematic review and meta-analysis of observational studies
- Bilingual Status
- complete