Meta AnalysisID 1567
丁苯酞治疗进展性脑梗死的系统评价与Meta分析
CRD42018115455
How effective is butylphthalide in the treatment of progressive cerebral infarction?
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Record Fields
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- Meta Analysis Id
- 1567
- Evidence Id
- 10125
- Core Evidence Id
- 10125
- Source Meta Analysis Id
- 1521
- Herb2 Meta Analysis Id
- HBMA001521
- Crd Id
- CRD42018115455
- Title
- Butylphthalide in the treatment of progressive cerebral infarction: a systematic review and meta-analysis of randomized controlled trials
- Review Question
- How effective is butylphthalide in the treatment of progressive cerebral infarction?
- Study Type Included
- We will include randomised trials to assess the beneficial effects of the treatments, and will supplement these with case for the assessment of harms.
- Condition Being Studied
- Progressive cerebral infarction (PCI) refers to the patients after cerebral infarction occurred over time the nerve function damage symptoms were gradually increasing trend, still is shown after clinical symptomatic treatment course of progressive or stepwise increase cerebral infarction.
- Participant
- Inclusion: Patients with a definite diagnosis of progressive cerebral infarction. Exclusion: Patients with cerebral hemorrhage.
- Animal
- Human Disease Modelled
- Intervention
- Butylphthalide
- Comparator Control
- Conventional treatment
- Main Outcome
- 1.Total effective rate Total effective rate, which depends predominantly on the change in neurological deficit score. According to the reduction of the neurological deficit score, the efficacy criteria can be divided into six grades: basic recovery, significant progress, progress, no change, deterioration and death. Basic recovery, significant progress, progress, no change, and deterioration are determined when the neurological deficit score decreased from 91% to 100%, from 46% to 90%, from 18% to 45%, by 17%, and increased respectively. Total effective rate (%) = (number of basic recovered patients + number of patients with significant progress+ number of patients with progress) / total number *100%. 2. Adverse drug reactions / adverse drug events (ADRs/ADEs) and number of death within the treatment and during the entire follow-up period. 3. Improvement of neurological impairment(NIHSS) 4.Activities of daily living function (Barthel Index) Measures of effect
- Outcome Measure
- Additional Outcome
- Serum inflammatory factor level：C-reactive protein（CRP） blood rheology index：Blood viscosity biochemical index：Homocysteine（Hcy）
- Study Method
- Systematic review
- Keyword
- 3-n-butylphthalide; Benzofurans; Cerebral Infarction; Databases, Genetic; Humans; Randomized Controlled Trials as Topic
- Contact
- Wei Bing [email protected]
- Organisational Affiliation
- Institute of Traditional Chinese Medicine
- Funding Source
- Postgraduate project.The funding comes from graduate student funds.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- Chinese-Trad
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2018-11-01
- Registration Date
- 2018-12-12
- Anticipated Start Date
- 2018-10-29
- Anticipated Completion Date
- 2019-12-31
- Title Cn
- 丁苯酞治疗进展性脑梗死的系统评价与Meta分析
- Title En
- Butylphthalide in the treatment of progressive cerebral infarction: a systematic review and meta-analysis of randomized controlled trials
- Bilingual Status
- complete