Meta AnalysisID 1559
铋对人肾脏的影响：系统评价
CRD42021270323
Does bismuth exert any, effects, conditions, or diseases in humans?
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 1559
- Evidence Id
- 10117
- Core Evidence Id
- 10117
- Source Meta Analysis Id
- 1513
- Herb2 Meta Analysis Id
- HBMA001513
- Crd Id
- CRD42021270323
- Title
- Bismuth effect in human kidneys: a systematic review
- Review Question
- Does bismuth exert any, effects, conditions, or diseases in humans?
- Study Type Included
- There will be no restrictions on the types of studies in the present review.
- Condition Being Studied
- Hydraulic calcium silicate-based reparative cement, such as mineral trioxide aggregate (MTA) is widely used in Endodontics since the 90s in procedures that include perforation sealing, pulp capping, apical surgeries, and apexification directly in contact with tissues and blood. The composition of such cement includes the presence of bismuth oxide working as a radiopacifying agent once the calcium silicate-based of these materials per se do not possess a radiopacity that fulfills the ISO 6876:2012. Bismuth is a very reactive material and interact chemically with dental structures. Recent studies have shown that there is a migration of bismuth ions from these materials to adjacent tissues. However, it is not known whether this ion accumulates or cause further effects, conditions, or diseases in human kidneys. Therefore, the objective of this systematic review will be to establish what has been reported regarding the accumulation of bismuth in human kidneys and its effects, conditions, or associated diseases.
- Participant
- Humans
- Animal
- Human Disease Modelled
- Intervention
- Subjects exposed to bismuth with kidney related effects, conditions, or associated diseases reported in the literature.
- Comparator Control
- The comparison will be with subjects not exposed to bismuth used as controls.
- Main Outcome
- This systematic review aims to investigate the kidney effects, conditions, or associated diseases associated with bismuth in humans. The measurements will consider biological samples and the ionic quantification of the ion, including articles in which the assessments were performed using either: atomic absorption spectrometry (AAS), electrothermal atomic absorption spectrometry (EAAS), flame atomic absorption spectrophotometry (FAAS), total reflection x-ray fluorescence (TXRF), inductively coupled plasma spectrometry (ICPs), or single-tube fluorimetric assay (STFA).
- Outcome Measure
- Additional Outcome
- Study Method
- Systematic review
- Keyword
- Bismuth; Humans; Kidney
- Contact
- Lauter Eston Pelepenko [email protected]
- Organisational Affiliation
- Unicamp - Piracicaba Dental School
- Funding Source
- FAPESP São Paulo Research Foundation Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> Process number: 2019/04614-0 and 2019/22098-9
- Other Selection Criteria
- Final Publication
- Effects of Bismuth Exposure on the Human Kidney—A Systematic Review https://doi.org/10.3390/antibiotics11121741
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Brazil
- Review Stage
- Review Completed published
- First Submission Date
- 2021-07-27
- Registration Date
- 2021-08-27
- Anticipated Start Date
- 2021-08-01
- Anticipated Completion Date
- 2022-12-01
- Title Cn
- 铋对人肾脏的影响：系统评价
- Title En
- Bismuth effect in human kidneys: a systematic review
- Bilingual Status
- complete