Meta AnalysisID 1556
铋、锆、钨和钽离子在人体内的全身蓄积：系统评价
CRD42020201227
Does bismuth, zirconium, tungsten, or tantalum ions systemically accumulate in humans?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 1556
- Evidence Id
- 10114
- Core Evidence Id
- 10114
- Source Meta Analysis Id
- 1510
- Herb2 Meta Analysis Id
- HBMA001510
- Crd Id
- CRD42020201227
- Title
- Bismuth, zirconium, tungsten, and tantalum ions systemic accumulation in humans: a systematic review
- Review Question
- Does bismuth, zirconium, tungsten, or tantalum ions systemically accumulate in humans?
- Study Type Included
- There will be no restrictions on the types of studies in the present review.
- Condition Being Studied
- Hydraulic calcium silicate-based reparative cement, such as mineral trioxide aggregate (MTA) is widely used in Endodontics since the 90s in procedures that include perforation sealing, pulp capping, apical surgeries, and apexification directly in contact with tissues and blood. The composition of such cement includes the presence of bismuth oxide, tantalum oxide, zirconium oxide, calcium tungstate, and associations working as radiopacifying agents once the calcium silicate-based of these materials per se do not possess a radiopacity that fulfills the ISO 6876. Radiopacifiers ions are very reactive and interact chemically with dental structures. Recent studies have shown that there is a migration of ions from these materials to adjacent tissues. However, it is not known whether these ions accumulate systematically from other sources. Therefore, the objective of this systematic review will be to establish what is known regarding the systemic accumulation of bismuth, zirconium, tungsten, or tantalum ions systemically in humans.
- Participant
- Humans.
- Animal
- Human Disease Modelled
- Intervention
- Subjects exposed to bismuth, zirconium, tungsten, or tantalum reported in the literature.
- Comparator Control
- The comparison will be with subjects not exposed to bismuth, tantalum, zirconium, or tungsten used as controls.
- Main Outcome
- This systematic review aims to investigate the systemic accumulation of bismuth, zirconium, tungsten, or tantalum ions systemically in humans. Measures of effect The accumulation measurements will consider biological samples and the ionic quantification of the ions, including articles in which the assessments were performed using either: atomic absorption spectrometry (AAS), electrothermal atomic absorption spectrometry (EAAS), flame atomic absorption spectrophotometry (FAAS), total reflection x-ray fluorescence (TXRF), inductively coupled plasma spectrometry (ICPs), or single-tube fluorimetric assay (STFA).
- Outcome Measure
- Additional Outcome
- None Measures of effect None
- Study Method
- Systematic review
- Keyword
- Bismuth; Humans; Ions; Tantalum; Tungsten; Zirconium
- Contact
- Lauter Eston Pelepenko [email protected]
- Organisational Affiliation
- Unicamp - Piracicaba Dental School
- Funding Source
- The São Paulo Research Foundation - FAPESP Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> Process number: 2019/04614-0
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English, Portuguese-Brazil, Spanish
- Country
- Brazil
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-07-27
- Registration Date
- 2020-08-27
- Anticipated Start Date
- 2020-09-01
- Anticipated Completion Date
- 2021-09-01
- Title Cn
- 铋、锆、钨和钽离子在人体内的全身蓄积：系统评价
- Title En
- Bismuth, zirconium, tungsten, and tantalum ions systemic accumulation in humans: a systematic review
- Bilingual Status
- complete