Meta AnalysisID 1552
抗酸剂、硫糖铝和铋盐治疗功能性消化不良[Cochrane方案]
CRD42017083215
Primary Effectiveness of antacids, sucralfate and bismuth salts in reducing overall functional dyspepsia symptoms in dyspeptic people. Secondary<ol> Quality of life Individual dyspepsia symptom change Adverse events and
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 1552
- Evidence Id
- 10110
- Core Evidence Id
- 10110
- Source Meta Analysis Id
- 1507
- Herb2 Meta Analysis Id
- HBMA001507
- Crd Id
- CRD42017083215
- Title
- Antacids, sucralfate and bismuth salts for functional dyspepsia [Cochrane protocol]
- Review Question
- Primary Effectiveness of antacids, sucralfate and bismuth salts in reducing overall functional dyspepsia symptoms in dyspeptic people. Secondary<ol> Quality of life Individual dyspepsia symptom change Adverse events and complications</ol>
- Study Type Included
- All experimental or interventional studies, without any limitation in type and details, that studied the effectiveness of three classes of drugs (antacids, sucralfate and bismuth salts) in the improvement of either individual or global dyspepsia.
- Condition Being Studied
- The Cochrane Upper GI and Pancreatic Diseases Group
- Participant
- We will include all participants over 18 years, of both genders, with a diagnosis of functional dyspepsia (functional or non-ulcer dyspepsia) according to any well-defined criteria (such as Rome I, II, III , IV or Lancet Working Group) . Studies that included other gastrointestinal diseases, such as peptic ulcer, organic dyspepsia and reflux disease will be excluded. This may be confirmed by checking if upper gastrointestinal endoscopy or any other diagnostic modality was performed in participant recruitment for the study. If a study included populations with different conditions, we will only include participants with functional dyspepsia. Participants in the trials that did not have any positive findings at endoscopy or barium study, symptoms of hiatus hernia, less than five gastric erosions or mild duodenitis will be included. We will include all participants, naive or with a history of treatment of FD and we will include all types of participant that were recruited in studies such as participants in primary care, secondary or tertiary care, or convenience sample.
- Animal
- Human Disease Modelled
- Intervention
- We will include trials comparing oral administration of any dose of any available drug (antacids, sucralfate and bismuth salts) with placebo. For technical reasons the intervention and comparators fields for Cochrane protocols are identical and each may include information on both interventions and comparators
- Comparator Control
- We will include trials comparing oral administration of any dose of any available drug (antacids, sucralfate and bismuth salts) with placebo. For technical reasons the intervention and comparators fields for Cochrane protocols are identical and each may include information on both interventions and comparators
- Main Outcome
- Effectiveness of the three classes of drugs (antacids, sucralfate and bismuth salts) in reducing overall functional dyspepsia symptoms.
- Outcome Measure
- Additional Outcome
- <ol> Quality of life score increment Individual dyspepsia symptoms score reduction or disappearance Adverse events</ol> <b>Time (duration of therapy)</b> We will consider interventions of at least four weeks duration (studies with outcome assessment carried out at less than four weeks will be excluded). The outcome measures will be considered mainly at the end of four weeks.
- Study Method
- Intervention, Systematic review
- Keyword
- Antacids; Bismuth; Dyspepsia; Humans; Salts; Sucralfate
- Contact
- Meisam Abdar Esfahani [email protected]
- Organisational Affiliation
- The Cochrane Collaboration http://www.cochrane.org/
- Funding Source
- McMaster University
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD012686/abstract
- Review Type
- Language
- English
- Country
- Iran
- Review Stage
- Review Ongoing
- First Submission Date
- Registration Date
- 2017-12-02
- Anticipated Start Date
- 2017-06-15
- Anticipated Completion Date
- 2018-04-01
- Title Cn
- 抗酸剂、硫糖铝和铋盐治疗功能性消化不良[Cochrane方案]
- Title En
- Antacids, sucralfate and bismuth salts for functional dyspepsia [Cochrane protocol]
- Bilingual Status
- complete