Meta AnalysisID 1539
血清胆汁酸与非酒精性脂肪性肝病之间的相关性：系统评价与Meta分析
CRD42022345481
The aims of this meta-analysis were to characterise the relationship between bile acid levels and NAFLD at the population level in Western and Eastern countries, and to estimate the differences in bile acid levels betwee
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 1539
- Evidence Id
- 10097
- Core Evidence Id
- 10097
- Source Meta Analysis Id
- 1494
- Herb2 Meta Analysis Id
- HBMA001494
- Crd Id
- CRD42022345481
- Title
- Correlation between serum bile acid and nonalcoholic fatty liver disease: A Systematic Review and Meta-Analysis.
- Review Question
- The aims of this meta-analysis were to characterise the relationship between bile acid levels and NAFLD at the population level in Western and Eastern countries, and to estimate the differences in bile acid levels between NAFLD and control groups.
- Study Type Included
- Observational research, including cross-sectional, case-control and cohort designs
- Condition Being Studied
- Nonalcoholic fatty liver disease has become the most common cause of chronic liver disease worldwide, with an estimated prevalence of 25% in the general population. The natural of history of nonalcoholic fatty liver disease encompasses a wide spectrum of liver damage ranging from the benign stage of simple nonalcoholic fatty liver to the progressive form of nonalcoholic steatohepatitis with or without fibrosis. And it has been reported to have an increased risk of mortality from causes such as cardiovascular disease, diabetes and malignancies, showing an enormous clinical and economical burden, but the exact etiology has still not been clearly elucidated.
- Participant
- Subjects with proven nonalcoholic fatty liver disease will be included.
- Animal
- Human Disease Modelled
- Intervention
- Detected serum bile acid levels were the main exposures.
- Comparator Control
- Healthy controls without nonalcoholic fatty liver disease
- Main Outcome
- Estimate the differences in bile acid levels between NAFLD and control groups at the population level in Western and Eastern countries. Measures of effect Risk difference, SMD, OR
- Outcome Measure
- Additional Outcome
- None Measures of effect None
- Study Method
- Epidemiologic, Meta-analysis, Systematic review
- Keyword
- Bile Acids and Salts; Biopsy; Humans; Non-alcoholic Fatty Liver Disease; Risk Factors
- Contact
- Ling Luo [email protected]
- Organisational Affiliation
- The First Affiliated Hospital, Sun Yat-sen University
- Funding Source
- National Natural Science Foundation of China (81870404, 82100648), Postdoctoral Research Foundation of China (2020M683128).
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-07-10
- Registration Date
- 2022-07-20
- Anticipated Start Date
- 2022-08-01
- Anticipated Completion Date
- 2023-08-01
- Title Cn
- 血清胆汁酸与非酒精性脂肪性肝病之间的相关性：系统评价与Meta分析
- Title En
- Correlation between serum bile acid and nonalcoholic fatty liver disease: A Systematic Review and Meta-Analysis.
- Bilingual Status
- complete