Meta AnalysisID 1537
血液胆汁酸代谢物生物标志物对肝硬化的预测价值：系统评价与Meta分析方案
CRD42021238193
This study aims to systematically review the change of bile acid metabolites in liver cirrhosis, revealing the relationship between the change of bile acid and the process of cirrhosis, attempting to explore the potentia
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 1537
- Evidence Id
- 10095
- Core Evidence Id
- 10095
- Source Meta Analysis Id
- 1493
- Herb2 Meta Analysis Id
- HBMA001493
- Crd Id
- CRD42021238193
- Title
- Predictive value of liver cirrhosis using metabolite biomarkers of bile acid in the blood: A protocol for systematic review and meta-analysis
- Review Question
- This study aims to systematically review the change of bile acid metabolites in liver cirrhosis, revealing the relationship between the change of bile acid and the process of cirrhosis, attempting to explore the potential biomarkers which can predict cirrhosis.
- Study Type Included
- We will include clinical studies based on human including randomized controlled trial, cohort study and case control study without restriction of time, however languages are English and Chinese.
- Condition Being Studied
- Liver cirrhosis is the end stage liver disease resulting from continuous intra-hepatic inflammation and extracellular matrix (ECM) accumulation caused by uncontrolled chronic liver diseases. Previous studies have indicated that bile acid is associated with progression of liver cirrhosis. However, the particular role of specific bile acid in the development of liver cirrhosis is not definite. Thus, the aim of this review is to explore the potential biomarkers which can predict cirrhosis.
- Participant
- Adult patients with a confirmed clinical diagnosis of Liver Cirrhosis will be included in the study. Exclude: The pregnancy; cirrhosis patient with other liver disease including hepatic encephalopathy and hepatocellular carcinoma.
- Animal
- Human Disease Modelled
- Intervention
- The metebolomic profile of bile acid in blood sample which are measured and analysed using metabolomic techniques.
- Comparator Control
- Healthy people will serve as controls whose metabolomics profile of bile acid using the same way as in patients with cirrhosis.
- Main Outcome
- The different metabolomics profile of bile acid between the cirrhosis and the healthy, which could become a biomarker in order to predictively diagnose cirrhosis. And their concentration will be aggregated as a primary outcome to perform a meta-analysis. Measures of effect We will report outcomes as mean difference (MD) and standard deviation (SD) for continuous outcomes.
- Outcome Measure
- Additional Outcome
- None. Measures of effect Not applicable
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Bile Acids and Salts; Biomarkers; Humans; Liver Cirrhosis
- Contact
- Xu Han [email protected]
- Organisational Affiliation
- Institute Of Basic Research In Clinical Medicine, China Academy Of Chinese Medical Sciences
- Funding Source
- Other Selection Criteria
- Final Publication
- Han, X., Wang, J., Gu, H., Guo, H., Cai, Y., Liao, X., & Jiang, M. (2022). Predictive value of serum bile acids as metabolite biomarkers for liver cirrhosis: a systematic review and meta-analysis. Metabolomics : Official journal of the Metabolomic Society, 18(7), 43. https://doi.org/10.1007/s11306-022-01890-y
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Completed published
- First Submission Date
- 2021-02-21
- Registration Date
- 2021-04-15
- Anticipated Start Date
- 2021-02-01
- Anticipated Completion Date
- 2021-11-30
- Title Cn
- 血液胆汁酸代谢物生物标志物对肝硬化的预测价值：系统评价与Meta分析方案
- Title En
- Predictive value of liver cirrhosis using metabolite biomarkers of bile acid in the blood: A protocol for systematic review and meta-analysis
- Bilingual Status
- complete