Meta AnalysisID 1536
靶向胆汁酸代谢以减重：系统评价与Meta分析
CRD42018115768
1. How bile acid metabolism and signaling is associated with obesity incidence 2. How obesity treatment affects bile acid metabolism and signaling
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Record Fields
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- Meta Analysis Id
- 1536
- Evidence Id
- 10094
- Core Evidence Id
- 10094
- Source Meta Analysis Id
- 1492
- Herb2 Meta Analysis Id
- HBMA001492
- Crd Id
- CRD42018115768
- Title
- Targeting bile acid metabolism in obesity reduction: a systematic review and meta-analysis
- Review Question
- 1. How bile acid metabolism and signaling is associated with obesity incidence 2. How obesity treatment affects bile acid metabolism and signaling
- Study Type Included
- Randomised or non-randomised controlled trials studying effect of obesity reduction treatment and observational studies that evaluate the association of obesity with bile acid metabolism and signaling pathway will be included. The following study/publication types will be excluded: • Pre-clinical and animal • Protocols • Reviews, editorials, and opinion pieces • Case reports
- Condition Being Studied
- Obesity is a growing global issue and diet plays an inevitable role. Our understanding of bile acid as important hormone that regulates metabolism has been substantially improved by animal and human studies. High fat diet has been shown to induce obesity through bile acid signaling pathway, especially the FXR-fgf19 pathway, as proven by the FXR-knockout mice model. Considerable experimental evidence also links bile acid levels to different obesity treatment options. Several reviews have been highlighting the effect of bariatric surgery on bile acid level, yet, no statistical analysis is done. At present, we also lack detailed analysis on the association of bile acid with obesity in humans. Together, this led us to review the association of bile acid level with obesity and the significance of bile acid in obesity reduction.
- Participant
- Adults and adolescents. Infants, children and elderlies excluded as literature reported a different bile acid level and profile in them compared to adults.
- Animal
- Human Disease Modelled
- Intervention
- Studies will be eligible if they meet all the following criteria: Human study Adolescents and adult population Original peer-reviewed English written journals characterisation of obesity based on BMI, waist circumference, waist-to-hip ratio, visceral or subcutaneous adipose tissue, percentage of body fat Bile acid-related parameters measured Including a lean control group (for review question 1) or an effective treatment method with comparison with baseline or non-treated patients(for review question 2)
- Comparator Control
- Obese patients compared with lean control group (for review question 1) Obese patients received obesity reduction treatment compared with patients with no treatment (for review question 2) Obese patients received obesity reduction treatment compared with baseline (before treatment) (for review question 2)
- Main Outcome
- The following outcomes will be considered: Bile acid and related parameters level Obesity severity/incidence Measures of effect Risk difference
- Outcome Measure
- Additional Outcome
- None Measures of effect Not applicable
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Bile Acids and Salts; Biochemical Phenomena; Humans; Lipid Metabolism; Obesity
- Contact
- Stephanie So [email protected]
- Organisational Affiliation
- The University of Hong Kong
- Funding Source
- Other Selection Criteria
- Final Publication
- https://onlinelibrary.wiley.com/doi/abs/10.1111/obr.13017
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Hong Kong
- Review Stage
- Review Completed published
- First Submission Date
- 2018-11-05
- Registration Date
- 2018-12-14
- Anticipated Start Date
- 2018-11-01
- Anticipated Completion Date
- 2019-02-01
- Title Cn
- 靶向胆汁酸代谢以减重：系统评价与Meta分析
- Title En
- Targeting bile acid metabolism in obesity reduction: a systematic review and meta-analysis
- Bilingual Status
- complete