Meta AnalysisID 1535
根据胆汁酸水平评估的妊娠期肝内胆汁淤积症相关产科结局：系统评价与Meta分析
CRD42018111642
To quantify the association between different severities of ICP (intrahepatic cholestasis of pregnancy, TBA 10-39, 40-99, and > 100 micromol/L) and perinatal death.
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 1535
- Evidence Id
- 10093
- Core Evidence Id
- 10093
- Source Meta Analysis Id
- 1491
- Herb2 Meta Analysis Id
- HBMA001491
- Crd Id
- CRD42018111642
- Title
- Obstetric outcomes as assessed by bile acid levels associated with intrahepatic cholestasis of pregnancy: a systematic review and meta-analysis
- Review Question
- To quantify the association between different severities of ICP (intrahepatic cholestasis of pregnancy, TBA 10-39, 40-99, and > 100 micromol/L) and perinatal death.
- Study Type Included
- Retrospective cohort studies/case series.
- Condition Being Studied
- Intrahepatic cholestasis of pregnancy (ICP) is a multifactorial disorder, characterized by an elevation of total bile acids (TBA), usually associated with abnormal liver enzyme levels and pruritus without skin rashes or primary skin lesions, and typically developing during the second half of pregnancy.
- Participant
- Women with singleton pregnancies affected by ICP (TBA > 10 micromol/L).
- Animal
- Human Disease Modelled
- Intervention
- No intervention. This review is a retrospective study of obstetric outcomes, as assessed by bile acid levels associated with intrahepatic cholestasis of pregnancy.
- Comparator Control
- No control.
- Main Outcome
- Perinatal death, defined as including both stillbirths (defined as a fetal death ≥ 20 weeks, or as defined by authors), and neonatal deaths (deaths before 28 days of life). Measures of effect Baseline demographic data for each of the ICP groups within each study is collected and standard means are calculated. Pregnancy and neonatal outcomes are collected for each of the ICP groups. Differences between outcomes are analyzed using a Pearson χ² for categorical outcomes. When the probability values are noted to be significantly different between groups, Fisher’s exact test is used to analyze the difference between each paired group to further detail the interaction. Continuous outcomes are compared using metaregression with inverse variance weighting using reported sample sizes and standard deviations. Pairwise comparisons use a Bonferroni correction to control for multiple testing. Statistical analyses are performed in SPSS software version 24 (SPSS Inc., Chicago, IL). Probability values of <.05 are considered statistically significant.
- Outcome Measure
- Additional Outcome
- Gestational age (GA) at delivery, spontaneous or iatrogenic labor, spontaneous or iatrogenic preterm birth (sPTB or iPTB) (defined as gestational age < 37 weeks), cesarean delivery (CD), meconium-stained amniotic fluid, postpartum hemorrhage (PPH), (defined as blood loss > 1000 mL), admission to NICU, birthweight, small for gestational age (SGA) (defined as birthweight < 10th percentile), and low Apgar score (< 7) at 5 minutes. Measures of effect Differences between outcomes are analyzed using a Pearson χ² for categorical outcomes. When the probability values are noted to be significantly different between groups, Fisher’s exact test is used to analyze the difference between each paired group to further detail the interaction. Continuous outcomes are compared using metaregression with inverse variance weighting using reported sample sizes and standard deviations. Pairwise comparisons use a Bonferroni correction to control for multiple testing.
- Study Method
- Diagnostic, Epidemiologic, Meta-analysis, Systematic review
- Keyword
- Bile Acids and Salts; Cholestasis, Intrahepatic; Diagnostic Techniques, Obstetrical and Gynecological; Female; Humans; Infant Death; Infant Health; Infant, Newborn; Intrahepatic Cholestasis of Pregnancy; Maternal Health; Perinatal Death; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Stillbirth
- Contact
- Daniele Di Mascio [email protected]
- Organisational Affiliation
- Department of Gynecological, Obstetrical and Urological Sciences “Sapienza University of Rome <h1>Review team members and their organisational affiliations <span class=fieldcount title=Total number of changes made to this field> [1 change]</span></h1> Dr Daniele Di Mascio. Department of Gynecological, Obstetrical and Urological Sciences, Sapienza Professor Vincenzo Berghella. MFM Dept - TJUH Dr Johanna Quist-Nelson. MFM Dept - TJUH<h1>Type and method of review</h1> Diagnostic, Epidemiologic, Meta-analysis, Systematic review<h1>Anticipated or actual start date</h1> 05 September 2018<h1>Anticipated completion date</h1> 02 November 2018<h1>Funding sources/sponsors</h1> None <h1>Conflicts of interest</h1> <h1>Language</h1> English<h1>Country</h1> Italy, United States of America<h1>Stage of review <span class=fieldcount title=Total number of changes made to this field> [1 change]</span></h1> Review Completed published<h1>Details of final report/publication(s) or preprints if available <span class=fieldcount title=Total number of changes made to this field> [1 change]</span></h1>
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Review Stage
- First Submission Date
- Registration Date
- Anticipated Start Date
- Anticipated Completion Date
- Title Cn
- 根据胆汁酸水平评估的妊娠期肝内胆汁淤积症相关产科结局：系统评价与Meta分析
- Title En
- Obstetric outcomes as assessed by bile acid levels associated with intrahepatic cholestasis of pregnancy: a systematic review and meta-analysis
- Bilingual Status
- complete