Meta AnalysisID 1529
胆汁酸螯合剂对血糖控制的影响：随机对照试验的系统评价与Meta分析
CRD42012002552
To assess the effects and adverse events of bile acid sequestrants in patients with type 2 diabetes.
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 1529
- Evidence Id
- 10087
- Core Evidence Id
- 10087
- Source Meta Analysis Id
- 1484
- Herb2 Meta Analysis Id
- HBMA001484
- Crd Id
- CRD42012002552
- Title
- Effect of bile acid sequestrants on glycaemic control: a systematic review and meta-analysis of randomised controlled trials
- Review Question
- To assess the effects and adverse events of bile acid sequestrants in patients with type 2 diabetes.
- Study Type Included
- The review will include randomised controlled trials, irrespective of blinding, publication status, or language. The first period of cross over trials will be included. Unpublished trials will be included if the methodology and data are accessible in written form.
- Condition Being Studied
- Type 2 diabetes mellitus (T2DM) is a severe metabolic disease characterised by relative insulin deficiency, including defect insulin secretion, insulin resistance, inappropriate glucagon secretion and impaired incretin effect resulting in fasting and postprandial hyperglycaemia. T2DM is also associated with overweight and dyslipidaemia and carries long-term risk of micro and macrovascular disease.
- Participant
- Adult patients (at least 18 years of age) of both genders with T2DM will be included. Inclusion criteria should be reported in the included trials. Ideally, the diagnostic criteria for T2DM should be based on the criteria of the WHO, the American Diabetes Association (ADA) or the European Association for the Study of Diabetes (EASD), but if necessary, trials will be included with the authors’ definition of T2DM.
- Animal
- Human Disease Modelled
- Intervention
- The intervention comparisons will include all types of bile acid sequestrants (colestyramine, colestimide, colestipol, colestilan and colesevelam) versus placebo.
- Comparator Control
- Co-interventions with other anti-diabetic agents will be accepted if administered to the intervention and control group.
- Main Outcome
- HbA1c
- Outcome Measure
- Additional Outcome
- Fasting plasma glucose (FPG). LDL-cholesterol. HDL-cholesterol. Total-cholesterol. Triglycerides, Body mass index (BMI). Adverse events: Adverse events will be defined based on the international guidelines for good clinical practice as any untoward medical occurrence.
- Study Method
- Intervention, Meta-analysis
- Keyword
- Allylamine; Bile Acids and Salts; Fluorobenzenes; Humans; Hypoglycemic Agents; Pyrimidines; Sulfonamides
- Contact
- Morten Hansen [email protected]
- Organisational Affiliation
- Diabetes Research Division
- Funding Source
- The work has not received funding.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Denmark
- Review Stage
- Review Ongoing
- First Submission Date
- Registration Date
- 2012-06-27
- Anticipated Start Date
- 2012-07-02
- Anticipated Completion Date
- 2012-12-31
- Title Cn
- 胆汁酸螯合剂对血糖控制的影响：随机对照试验的系统评价与Meta分析
- Title En
- Effect of bile acid sequestrants on glycaemic control: a systematic review and meta-analysis of randomised controlled trials
- Bilingual Status
- complete