Meta AnalysisID 1519
补充肌肽或β-丙氨酸对人类和动物研究中血糖控制及胰岛素抵抗标志物的影响：系统评价与Meta分析方案
CRD42020191588
What is the effect of carnosine or beta-alanine supplementation on markers of glycaemic control and insulin resistance in humans and animals?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 1519
- Evidence Id
- 10077
- Core Evidence Id
- 10077
- Source Meta Analysis Id
- 1474
- Herb2 Meta Analysis Id
- HBMA001474
- Crd Id
- CRD42020191588
- Title
- The effect of carnosine or beta-alanine supplementation on markers of glycaemic control and insulin resistance in human and animal studies: a protocol for a systematic review and meta-analysis
- Review Question
- What is the effect of carnosine or beta-alanine supplementation on markers of glycaemic control and insulin resistance in humans and animals?
- Study Type Included
- Studies will be limited to non-randomised and randomised controlled trials (RCTs), including cluster RCTs. We will exclude cohort studies, cross-sectional studies, case series, case reports, commentary, and review articles.
- Condition Being Studied
- Glycaemic control and insulin resistance.
- Participant
- Humans with a diagnosis of type 1 diabetes, type 2 diabetes, prediabetes, gestational diabetes, impaired fasting glucose, or impaired glucose tolerance (according to World Health Organization guidelines); or humans with overweight/obesity (body mass index equal to or greater than 25 kg/m2) where the relevant outcomes were collected and reported. Animal studies with a relevant disease model (see criteria above). There will be no restriction on age or comorbidities; and no restrictions on the methods used to induce disease in animal studies.
- Animal
- Human Disease Modelled
- Intervention
- Supplementation with carnosine or beta-alanine. We will exclude studies that use a multi-ingredient supplement intervention. Human studies will include oral administration only, whereas in animal studies we will also consider administration by other means (e.g., intraperitoneal or intravenous injection).
- Comparator Control
- Comparisons for human studies will be between placebo and the experimental intervention. Comparisons for animal studies will be between placebo or control (no intervention) and the experimental intervention. Studies without a control or placebo group will be excluded.
- Main Outcome
- Primary outcomes include: 1) fasting glucose; 2) glycated haemoglobin, and 3) 2-hour glucose following a glucose tolerance test. Measures of effect Raw scale mean difference between intervention and control/placebo.
- Outcome Measure
- Additional Outcome
- Markers of glycaemic control and insulin resistance (e.g., fasting insulin, glucose tolerance test parameters, homeostatic model assessment parameters). Measures of effect Standardised mean difference between intervention and control/placebo.
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Animals; Biomarkers; Blood Glucose; Carnosine; Dietary Supplements; Humans; Insulin Resistance; beta-Alanine
- Contact
- Joseph J Matthews [email protected]
- Organisational Affiliation
- Nottingham Trent University (NTU).
- Funding Source
- None.
- Other Selection Criteria
- Final Publication
- https://academic.oup.com/advances/advance-article/doi/10.1093/advances/nmab087/6333366?searchresult=1
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- England
- Review Stage
- Review Completed published
- First Submission Date
- 2020-06-11
- Registration Date
- 2020-07-02
- Anticipated Start Date
- 2020-06-01
- Anticipated Completion Date
- 2021-01-31
- Title Cn
- 补充肌肽或β-丙氨酸对人类和动物研究中血糖控制及胰岛素抵抗标志物的影响：系统评价与Meta分析方案
- Title En
- The effect of carnosine or beta-alanine supplementation on markers of glycaemic control and insulin resistance in human and animal studies: a protocol for a systematic review and meta-analysis
- Bilingual Status
- complete