Meta AnalysisID 1516
碳酸氢钠与β-丙氨酸联合补充对身体能力和表现是否有协同效应？随机对照试验的系统评价与Meta分析
CRD42022378771
General consideration:a) Is there synergistic effect of sodium bicarbonate and beta-alanine co-supplementation on physical capacity and performance? Specific questions: a) Is there synergistic effect of sodium bicarbonat
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Record Fields
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- Meta Analysis Id
- 1516
- Evidence Id
- 10074
- Core Evidence Id
- 10074
- Source Meta Analysis Id
- 1471
- Herb2 Meta Analysis Id
- HBMA001471
- Crd Id
- CRD42022378771
- Title
- Is there a synergistic effect of sodium bicarbonate and beta-alanine co-supplementation on physical capacity and performance? A systematic review and meta-analysis of randomized controlled trials
- Review Question
- General consideration:a) Is there synergistic effect of sodium bicarbonate and beta-alanine co-supplementation on physical capacity and performance? Specific questions: a) Is there synergistic effect of sodium bicarbonate and beta-alanine co-supplementation on blood buffering capacity? b) Is there synergistic effect of sodium bicarbonate and beta-alanine co-supplementation on aerobic capacity? c) Is there synergistic effect of sodium bicarbonate and beta-alanine co-supplementation on anaerobic capacity? d) Is there synergistic effect of sodium bicarbonate and beta-alanine co-supplementation on discipline-specific performance?
- Study Type Included
- Inclusion criteria: a) interventional randomized and non-randomized placebo controlled parallel-group trials, b) interventional randomized and non-randomized placebo controlled cross-over trials. Exclusion criteria: a) single arm interventional studies, b) studies on in vitro models, c) studies on animals.
- Condition Being Studied
- Nutrition and supplementation are essential in obtaining and sustaining the highest possible level of physical capacity and performance, and eventually may improve sports results. Supplementation with either sodium bicarbonate or beta-alanine is relatively well examined regarding ergogenic effect. Ergogenic mechanism of action of sodium bicarbonate is related with an increase in intra-cellular buffering capacity. On the other hand, supplementation with beta-alanine leads to an increase in muscle carnosine concentration and eventually to enhacement in extra-cellular buffering capacity. There is a great body of evidence of ergogenic potential of separate supplementation with either sodium bicarbonate or beta-alanine. Still, the data of their potential synergistic action is limited and needs to be organized, and summarized. The latter will help to point directions of future studies on sodium bicarbonate and beta-alanine co-supplementation. Thus, the aim of the current systematic review and meta-analysis is to summarize the up-to-date body of evidence of supposed synergistic action of sodium bicarbonate and beta-alanine co-ingestion and an attempt to frame the recommendations on optimal supplementation strategies including: a) doses of both active ingredients (sodium bicarbonate and beta-alanine), b) period of ingestion or c) timing of ingestion before exercise.
- Participant
- Inclusion criteria: a) males and females, b) ≥18 years old, c) healthy individuals. Exclusion criteria: a) <18 years old, b) diseased individuals.
- Animal
- Human Disease Modelled
- Intervention
- The intervention is short-therm and long-term sodium bicarbonate and beta-alanine co-supplementation.
- Comparator Control
- The comparator will be placebo and/or sodium bicarbonate and beta-alanine supplemented separately.
- Main Outcome
- The main outcomes of current systematic review and meta-analysis will include changes in: a) blood biochemical indices of buffering capacity, b) aerobic and anaerobic capacity, c) discipline-specific performance. Measures of effect Mean difference, standarized mean difference, standard deviation, standard deviation of a mean
- Outcome Measure
- Additional Outcome
- Not applicable Measures of effect Not applicable
- Study Method
- Meta-analysis, Narrative synthesis, Systematic review
- Keyword
- Anaerobiosis; Dietary Supplements; Humans; Randomized Controlled Trials as Topic; Sodium Bicarbonate; beta-Alanine
- Contact
- Jakub Adamczewski [email protected]
- Organisational Affiliation
- Department of Sports Dietetics, Poznań University of Physical Education https://www.awf.poznan.pl/en/noz-sports-dietetics-eng
- Funding Source
- Not applicable Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> Not applicable
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Not applicable
- Published Protocol
- Review Type
- Language
- English
- Country
- Poland
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-12-05
- Registration Date
- 2022-12-16
- Anticipated Start Date
- 2022-12-01
- Anticipated Completion Date
- 2023-06-30
- Title Cn
- 碳酸氢钠与β-丙氨酸联合补充对身体能力和表现是否有协同效应？随机对照试验的系统评价与Meta分析
- Title En
- Is there a synergistic effect of sodium bicarbonate and beta-alanine co-supplementation on physical capacity and performance? A systematic review and meta-analysis of randomized controlled trials
- Bilingual Status
- complete