Meta AnalysisID 149
茶、茶多酚和茶提取物对啮齿动物模型骨结局影响的系统评价
CRD42021260381
Do tea, tea polyphenols or tea extract have beneficial effects on bone outcomes in rodent models [mouse, rat, guinea pig, hamster]? Context and rationale Camellia sinensis is a plant species within the Theaceae family, w
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Record Fields
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- Meta Analysis Id
- 149
- Evidence Id
- 8707
- Core Evidence Id
- 8707
- Source Meta Analysis Id
- 136
- Herb2 Meta Analysis Id
- HBMA000136
- Crd Id
- CRD42021260381
- Title
- Systematic review of the effect of tea, tea polyphenols and tea extract on bone outcomes in rodent models
- Review Question
- Do tea, tea polyphenols or tea extract have beneficial effects on bone outcomes in rodent models [mouse, rat, guinea pig, hamster]? Context and rationale Camellia sinensis is a plant species within the Theaceae family, whose leaves are used to produce a variety of teas including white, green, oolong and black tea. After water, tea is the second most widely consumed beverage in the world. Such teas are known to contain polyphenols which have been documented to have a range of protective effects on human health. These benefits can range from cardioprotective to chemoprotective and are a result of the antioxidant, anti-inflammatory and antimutagenic properties of tea. Current animal-based research also suggests that consumption of tea, tea polyphenols or tea polyphenol extract may have benefits for bone metabolism and overall bone health. Specifically, tea has shown to be protective against bone loss and reducing fracture risk, especially in rodent models of osteoporosis. Some but not all epidemiological studies have displayed associations between tea consumption and the prevention of age-related bone loss in both elderly women and men. This may be in part due to the oxidative stress that is suggested to play a role in the development of osteoporosis, mediated by the antioxidant activity of tea polyphenols. Thus, it is proposed that through the antioxidant properties of tea and its polyphenols, it can downregulate such mechanisms and promote bone health. The findings of this investigation will help to inform future research pertaining to preclinical studies investigating the effects of tea on bone health and may also inform future studies in humans. The preclinical studies that are included in this systematic review are used to model changes in bone health throughout the lifespan with the ultimate goal of preventing or managing osteoporosis. Osteoporosis is characterized by a loss of bone mineral and bone structure that leads to an increased risk of fracture.
- Study Type Included
- Inclusion criteria: We will include rodent studies with an in vivo tea, tea polyphenol(s) or tea extract intervention that analyzed the described outcome measures. Exclusion criteria: In vitro or ex vivo studies without an in vivo intervention to tea, tea polyphenols or tea extract will be excluded.
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: Pre-clinical in vivo rodent model [mouse, rat, guinea pig, hamster] in which tea and/or tea polyphenols and/or tea extract are provided while measuring bone outcomes. Studies using males and/or females will be included. Exclusion criteria: Animal models other than rodents or ex vivo studies or in vitro studies or human studies or in silico studies.
- Human Disease Modelled
- Osteoporosis
- Intervention
- Inclusion criteria: Form: tea or polyphenols or extract from Camellia sinensis Route of administration: oral administration (gavage or free access). Frequency of administration: at least once per day (oral gavage) or free access (in drinking water or food). Dose: any level Duration: any duration Exclusion criteria: Tea, tea polyphenols or tea extract not derived from Camellia sinensis. Study does not meet inclusion criteria in terms of frequency and/or route of administration.
- Comparator Control
- Inclusion criteria: Studies comparing placebo/no tea, tea polyphenol or tea extract exposure. Diet during intervention must be the same between intervention and comparator groups. Exclusion criteria: Studies with no comparator group(s) will be excluded.
- Main Outcome
- Outcome Measure
- Inclusion criteria: All data available for methods used to analyze bone including calipers/measuring tape, dual energy X-ray absorptiometry, micro-computed tomography, mechanical strength testing, micro-indentation, bone ashing, histology, dynamic bone histomorphometry, specific bone cell staining, blood biomarkers related to bone formation or resorption. Exclusion criteria: None of the specified bone outcomes reported.
- Additional Outcome
- Study Method
- Keyword
- Animals; Flavonoids; Plant Extracts; Polyphenols; Rodentia; Tea
- Contact
- Rebekah Feld [email protected]
- Organisational Affiliation
- Brock University https://brocku.ca
- Funding Source
- Funding provided through a Natural Science and Engineering Research Council (NSERC) Undergraduate Student Research Award (USRA) to Rebekah Feld. NSERC Discovery Grant and Canada Research Chair in Bone and Muscle Development to Wendy Ward. Grant number(s) Grant # RGPIN 2021-04113
- Other Selection Criteria
- Published research articles will be included in the search. A dissertation/thesis will also be included in the search though we will determine if a published paper has resulted from a dissertation/thesis that was found in the search and we will use the published paper (to avoid duplication by including both the dissertation/thesis and the resultant publication). Research in progress and conference proceedings/abstracts will be excluded since these forms of research have not yet undergone rigorous peer-review. Only full text articles in English will be included in this review, with no restriction on publication date.
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Experimental animal exposure review, Pre-clinical animal intervention review
- Language
- English
- Country
- Canada
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-06-10
- Registration Date
- 2021-07-09
- Anticipated Start Date
- 2021-06-01
- Anticipated Completion Date
- 2024-03-01
- Title Cn
- 茶、茶多酚和茶提取物对啮齿动物模型骨结局影响的系统评价
- Title En
- Systematic review of the effect of tea, tea polyphenols and tea extract on bone outcomes in rodent models
- Bilingual Status
- complete