Meta AnalysisID 1469
苯并噻唑类似物的抗疟活性：一项系统评价
CRD42017082321
We aim to systematically review antimalarial activities of benzothiazole analogues with their related structures and antimalarial mechanisms.
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Record Fields
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- Meta Analysis Id
- 1469
- Evidence Id
- 10027
- Core Evidence Id
- 10027
- Source Meta Analysis Id
- 1424
- Herb2 Meta Analysis Id
- HBMA001424
- Crd Id
- CRD42017082321
- Title
- Antimalarial activities of benzothiazole analogues: a systematic review
- Review Question
- We aim to systematically review antimalarial activities of benzothiazole analogues with their related structures and antimalarial mechanisms.
- Study Type Included
- No restriction to any study design.
- Condition Being Studied
- Malaria is a parasitic disease estimated to cause 429000 death globally in 2015 among 212 million cases (1). Several Plasmodium falciparum strains showed resistance to the marketable antimalarial drugs (2). Thus, the need to develop new antimalarial drugs to manage the resistance is increasing. Benzothiazole derivatives have been reported to have antimalarial activities, with some analogues showing good activity against chloroquine resistant strains (3). The aim of this study is to summarize chemical compounds containing benzothiazole with antimalarial activity. References: 1. WHO. World Malaria Report. World Health Organization. 2016. 1-186 p. 2. Dondorp AM, Yeung S, White L, Nguon C, Day NPJ, Socheat D, et al. Artemisinin resistance: current status and scenarios for containment. Nat Rev Microbiol [Internet]. Nature Publishing Group; 2010;8(4):272–80. Available from: http://www.nature.com/doifinder/10.1038/nrmicro2331 3. Ongarora DSB, Gut J, Rosenthal PJ, Masimirembwa CM, Chibale K. Benzoheterocyclic amodiaquine analogues with potent antiplasmodial activity: Synthesis and pharmacological evaluation. Bioorganic Med Chem Lett [Internet]. Elsevier Ltd; 2012;22(15):5046–50. Available from: http://dx.doi.org/10.1016/j.bmcl.2012.06.010
- Participant
- Inclusion criteria: 1-Original publication reporting antimalarial activity of different chemical compounds containing benzothiazole. 2-No restriction made for language and study design. 3-Effect on human, animal and in vitro. Exclusion criteria: 1-Unreliably extracted data. 2-Only abstract studies or studies where full paper not available. 3-Abstract articles only, books, conference, thesis and case reports. 4-Overlapped data sets.
- Animal
- Human Disease Modelled
- Intervention
- Antimalarial effect of compounds containing benzothiazole.
- Comparator Control
- Control will be added when exist.
- Main Outcome
- -Antimalarial activity of the compounds represented as the half maximal inhibitory concentration (IC50) values, % of parasite inhibition, etc. -Antimalarial mechanisms of these compounds -Role of chemical groups on the antimalarial activities
- Outcome Measure
- Additional Outcome
- -Cytotoxicity and metabolic parameters. -Adverse effects on human.
- Study Method
- Intervention, Pre-clinical, Systematic review
- Keyword
- Antimalarials; Benzothiazoles; Humans; Inorganic Chemicals; benzothiazole
- Contact
- Ahmed Mostafa Ahmed Kamel [email protected]
- Organisational Affiliation
- Faculty of Pharmacy, Minia University, Minia, Egypt.
- Funding Source
- None.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Bangladesh, Japan, Vietnam, Egypt
- Review Stage
- Review Ongoing
- First Submission Date
- 2017-11-25
- Registration Date
- 2017-12-19
- Anticipated Start Date
- 2017-10-05
- Anticipated Completion Date
- 2018-01-01
- Title Cn
- 苯并噻唑类似物的抗疟活性：一项系统评价
- Title En
- Antimalarial activities of benzothiazole analogues: a systematic review
- Bilingual Status
- complete