Meta AnalysisID 1468
附加使用苯甲酸钠（一种D-氨基酸氧化酶抑制剂）治疗精神分裂症的有效性和安全性：一项系统评价与Meta分析
CRD42021254093
Can add-on sodium benzoate improve the clinical outcome in patients with schizophrenia?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 1468
- Evidence Id
- 10026
- Core Evidence Id
- 10026
- Source Meta Analysis Id
- 1423
- Herb2 Meta Analysis Id
- HBMA001423
- Crd Id
- CRD42021254093
- Title
- Efficacy and safety of add-on sodium benzoate, a D-amino Acid Oxidase Inhibitor, in treatment of schizophrenia: A systematic review and meta-analysis
- Review Question
- Can add-on sodium benzoate improve the clinical outcome in patients with schizophrenia?
- Study Type Included
- Randomized controlled trials. Randomized clinical trials that have evaluated the effect of sodium benzoate for the treatment of schizophrenia to improve symptoms with PANSS will be included in this meta-analysis. Review articles, letter to the editor, comments, case series, case reports and studies where it was impossible to retrieve or calculate data of interest will be excluded from this meta-analysis.
- Condition Being Studied
- Schizophrenia
- Participant
- Inclusion criteria: • Adult patients, 15 years or over of either gender with a diagnosis of schizophrenia fulfilling DSM diagnostic criteria. • Patients remained symptomatic but without clinically significant fluctuation and the antipsychotic doses were unchanged for at least 3 months prior to recruitment in the trial. • Patients had a minimum baseline total score of 55 on the Positive and Negative Syndrome Scale (PANSS). Exclusion criteria • Schizoaffective disorder. • Mental retardation. • Substance (including alcohol) abuse or dependence. • History of epilepsy, head trauma, or central nervous system diseases. • Comorbid physical illnesses requiring additional treatments or hospitalizations. • Pregnancy or lactation. • Patients allergic to sodium benzoate or food preservatives.
- Animal
- Human Disease Modelled
- Intervention
- Sodium benzoate 1000-2000 mg per day as an adjunctive therapy to the current standard treatment for schizophrenia.
- Comparator Control
- Add-on placebo or any other NMDA-enhancing agents will be considered as a comparator.
- Main Outcome
- Mean change in the Positive and Negative Syndrome Scale (PANSS) score over the study period Measures of effect Mean difference with 95% CI
- Outcome Measure
- Additional Outcome
- 1. Change in composite neurocognitive domain score. 2. Change in Global Assessment of Function (GAF). 3. Change in Clinical Global Impression Scale (CGI). 4. Change in quality of life scale (QOLS) score. 5. Treatment (sodium benzoate) emergent adverse drug reactions. Measures of effect 1-4: Mean difference with 95% CI 5: Odds ratio with 95% CI
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Amino Acids; Antipsychotic Agents; D-Amino-Acid Oxidase; Humans; Schizophrenia; Sodium Benzoate
- Contact
- RITUPARNA MAITI [email protected]
- Organisational Affiliation
- AIIMS, Bhubaneswar, India https://aiimsbhubaneswar.nic.in/
- Funding Source
- Other Selection Criteria
- Final Publication
- Seetharam JC, Maiti R, Mishra A, Mishra BR. Efficacy and safety of add-on sodium benzoate, a D-amino acid oxidase inhibitor, in treatment of schizophrenia: A systematic review and meta-analysis. Asian J Psychiatr. 2022 Feb;68:102947. doi: 10.1016/j.ajp.2021.102947. Epub 2021 Nov 30. PMID: 34890931. https://PubMed.ncbi.nlm.nih.gov/34890931/
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- India
- Review Stage
- Review Completed published
- First Submission Date
- 2021-05-10
- Registration Date
- 2021-06-09
- Anticipated Start Date
- 2021-05-21
- Anticipated Completion Date
- 2021-06-30
- Title Cn
- 附加使用苯甲酸钠（一种D-氨基酸氧化酶抑制剂）治疗精神分裂症的有效性和安全性：一项系统评价与Meta分析
- Title En
- Efficacy and safety of add-on sodium benzoate, a D-amino Acid Oxidase Inhibitor, in treatment of schizophrenia: A systematic review and meta-analysis
- Bilingual Status
- complete