Meta AnalysisID 1461
不同剂量阿托品用于近视控制对近视个体屈光度和眼轴长度的影响：一项伞状系统评价
CRD42023394079
What is the effectiveness of the different doses of atropine in slowing the progression of the refraction and axial length for myopia control in myopic individuals?
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Record Fields
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- Meta Analysis Id
- 1461
- Evidence Id
- 10019
- Core Evidence Id
- 10019
- Source Meta Analysis Id
- 1415
- Herb2 Meta Analysis Id
- HBMA001415
- Crd Id
- CRD42023394079
- Title
- The effects of different atropine doses on refraction and axial length as myopia control in myopic individuals: A systematic umbrella review.
- Review Question
- What is the effectiveness of the different doses of atropine in slowing the progression of the refraction and axial length for myopia control in myopic individuals?
- Study Type Included
- This umbrella will consider systematic quantitative reviews with meta-analyses, which include a comprehensive search strategy and evidence of critical appraisal of the included studies using a standardised tool. Systematic reviews published from inception to maximise search results and in English will be included. Systematic reviews with no access to full text will also be excluded.
- Condition Being Studied
- Myopia is also referred to as near-sightedness or short-sightedness. Myopia happens when the eyeball is longer than normal and increased curvature of the cornea (Islam et al., 2022). Myopia increases the risk of ocular comorbidities such as cataracts, myopic macular degeneration, retinal detachment, and glaucoma, which can lead to blindness (Wong et al., 2014). Atropine is an anticholinergic drug that has been shown to be consistently effective in myopia control (Huang et al., 2016). There are different atropine doses: 0.01%, 0.02%, 0.025%, 0.05%, 0.1%, 0.5% and 1%. Many further trials, following the Atropine in the Treatment of Myopia (ATOM1) study and Low-Concentration Atropine for Myopia Progression (LAMP) Study, have demonstrated the safety and efficacy of varied doses of atropine in myopia control. With the increasing number of recent systematic reviews with meta-analyses, this umbrella review will yield a substantial number of systematic reviews with meta-analyses on atropine. The review can contribute by examining and synthesising the scientific evidence from the current systematic reviews.
- Participant
- Inclusion: Individuals diagnosed with myopia are defined as refraction ≤ −0.25 dioptres, with or without astigmatism. Systematic reviews that include adults in the meta-analysis will be included. Exclusion: Individuals underwent surgical intervention for myopia control.
- Animal
- Human Disease Modelled
- Intervention
- Inclusion: The umbrella review will consider systematic reviews that include atropine intervention for myopia control. This may include doses of 0.01%, 0.02%, 0.025%, 0.05%, 0.1%, 0.5% and 1%. Exclusion: Intervention without using atropine.
- Comparator Control
- We will include studies in which atropine intervention for myopia control was compared to other non-pharmacological therapy (for example, single-vision spectacles or a placebo) - no restriction on the duration and dose of treatment.
- Main Outcome
- A myopia control study’s key outcome measurements are commonly refractive error and axial length (Flitcroft et al., 2019). This review will consider systematic reviews that incorporate the following outcomes: refraction in dioptre (D) and axial length (AL) in millimetres (mm). Measures of effect Mean Difference, Standardised Mean Difference
- Outcome Measure
- Additional Outcome
- None Measures of effect None
- Study Method
- Meta-analysis, Review of reviews, Systematic review
- Keyword
- Atropine; Humans; Myopia; Refraction, Ocular; Vision Tests
- Contact
- Muhammad Hanzalah Bin Amren [email protected]
- Organisational Affiliation
- Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore https://medicine.nus.edu.sg/nursing/
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Singapore
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-01-24
- Registration Date
- 2023-02-04
- Anticipated Start Date
- 2022-12-20
- Anticipated Completion Date
- 2023-12-20
- Title Cn
- 不同剂量阿托品用于近视控制对近视个体屈光度和眼轴长度的影响：一项伞状系统评价
- Title En
- The effects of different atropine doses on refraction and axial length as myopia control in myopic individuals: A systematic umbrella review.
- Bilingual Status
- complete