Meta AnalysisID 1459
不同剂量阿托品治疗近视儿童的疗效与安全性比较：一项Meta分析
CRD42022377705
To evaluate the overall efficacy and safety of different doses of atropine with more updated studies and try to explore the dose-response relationship between different atropine concentrations and some main outcomes (ref
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Record Fields
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- Meta Analysis Id
- 1459
- Evidence Id
- 10017
- Core Evidence Id
- 10017
- Source Meta Analysis Id
- 1413
- Herb2 Meta Analysis Id
- HBMA001413
- Crd Id
- CRD42022377705
- Title
- Comparison of Efficacy and Safety of Varying Dose of Atropine for the Treatment of Myopic Children: A meta-analysis
- Review Question
- To evaluate the overall efficacy and safety of different doses of atropine with more updated studies and try to explore the dose-response relationship between different atropine concentrations and some main outcomes (refraction change, change of axial length, change of amplitude of accommodation, change of photopic pupil diameter), so as to find the most appropriate therapeutic concentration.
- Study Type Included
- We included cohort, case-control studies and RCTs according to the criteria:(1) atropine in at least one treatment arm and placebo/no intervention in another as the control; (2) age of participants under 18-year-old and had myopia(spherical equivalence, SE≤-0.5D); (3) reported annual rate of myopic progression (ie, refractive progression and elongation of axial length) and/or side effects of atropine therapy.
- Condition Being Studied
- Myopia, also known as nearsightedness, is caused by an imbalance between axial length and optical power, leading parallel lights to focus in front of the retina of eyes. Due to its global explosive epidemic among children and adolescents, it has recently become a significant public health concern. High myopia can significantly increase the risk of pathologic alterations that could ultimately result in blindness, such as posterior sclera staphyloma, retinal detachment, macular degeneration and choroidal neovascularization. Early-onset myopia usually progresses more quickly and invariably results in high myopia. Therefore, it is vital to slow or prevent myopic progression in children. Nowadays, except outdoor activities, no optimal strategy has yet been widely approved and accepted by doctors with enough safeness and clinical acceptability. Atropine is currently regarded as the most promising one and 0.01% atropine have already been utilized in the clinical management of childhood myopia in Asia. However, it reminds us some uncertainties and disagreements still persist— how to balance the increasing myopia control effect with higher dose against side effect is still an important issue and the optimal dose of atropine for myopia control is still controversial.
- Participant
- Inclusion: participants under 18-year-old and had myopia(spherical equivalence, SE≤-0.5D).
- Animal
- Human Disease Modelled
- Intervention
- Atropine intervention is defined as daily use of atropine sulfate or atropine gel. Patients can wear single-vision spectacle during the day when they need to see near or photochromic glasses when they are intolerable to photophobia.
- Comparator Control
- One treatment arm with placebo/no intervention is used as control group.
- Main Outcome
- Spherical equivalent, Axial length, Amplitude of Accommodation, Photopic pupil diameter. Measures of effect Weighed mean difference(WMD), Standardized mean difference(SMD).
- Outcome Measure
- Additional Outcome
- Rapid Myopia Progression (>1.0 D per Year), Slow Myopia Progression (<0.5 D per Year), BCVA, Astigmatism, Anterior chamber depth (ACD), Corneal curvature, Intraocular pressure (IOP), Lens thickness(LT), Photophobia, Blurred near vision, Allergic reactions. Measures of effect Weighed mean difference(WMD), Odds ratio(ORs).
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Accommodation, Ocular; Atropine; Child; Humans; Myopia; Pupil; Refraction, Ocular
- Contact
- Peixian Hou [email protected]
- Organisational Affiliation
- Department of Opthalmology, West China Hospital, Sichuan University
- Funding Source
- None. Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> None.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-11-21
- Registration Date
- 2022-12-02
- Anticipated Start Date
- 2022-10-23
- Anticipated Completion Date
- 2022-12-21
- Title Cn
- 不同剂量阿托品治疗近视儿童的疗效与安全性比较：一项Meta分析
- Title En
- Comparison of Efficacy and Safety of Varying Dose of Atropine for the Treatment of Myopic Children: A meta-analysis
- Bilingual Status
- complete