Meta AnalysisID 1425
天冬氨酸转氨酶-淋巴细胞比值指数（ALRI）在结直肠癌患者中的预后作用
CRD42022326700
The aim of this study is to investigate the prognostic role of aspartate aminotransferase-lymphocyte ratio index in patients with metastatic colorectal cancer.
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 1425
- Evidence Id
- 9983
- Core Evidence Id
- 9983
- Source Meta Analysis Id
- 1380
- Herb2 Meta Analysis Id
- HBMA001380
- Crd Id
- CRD42022326700
- Title
- Prognostic role of aspartate aminotransferase-lymphocyte ratio index (ALRI) in patients with colorectal cancer
- Review Question
- The aim of this study is to investigate the prognostic role of aspartate aminotransferase-lymphocyte ratio index in patients with metastatic colorectal cancer.
- Study Type Included
- No resrictions
- Condition Being Studied
- Colorectal cancer (CRC) is the third most common cause of death from cancer in Western Europe and North America. Literature has shown the relationship between systemic chronic inflammation and various types of cancer, including CRC. Accumulating evidence has indicated that the systemic inflammatory response (SIR) is pivotal in tumor development. Inflammation factors, such as aspartate aminotransferase-lymphocyte ratio index(ALRI), Glasgow Prognostic Score（GPS）, modified Glasgow Prognostic Score(mGPS), C-reactive protein（CRP).
- Participant
- The following inclusion criteria were used: (1) the diagnosis of CRC was made based on pathologic examination or the current ongoing clinical guidelines(2)articles investigating the relation of ALRI and prognosis for CRC; (3) ALRI levels were collected before any treatment such as the chemoradiotherapy, surgery, and neoadjuvant chemoradiotherapy; (4) full-text papers published; (5) the outcome of interest included OS, or DFS with hazards ratios (HRs) and corresponding 95% confidence intervals (CIs). The following exclusion criteria were used: (1) letters, editorials, expert opinions, case reports, abstract, s and reviews; (2) nonhuman studies; (3) if data sets were duplicated or overlapped, only the most recent information was included. (4) studies with insufficient data for estimating hazard ratio and 95% confidence interval. (5) studies were not written in English.
- Animal
- Human Disease Modelled
- Intervention
- patients with elevated aspartate aminotransferase-lymphocyte ratio index
- Comparator Control
- patients with low aspartate aminotransferase-lymphocyte ratio index
- Main Outcome
- overall survival Measures of effect HR, OR
- Outcome Measure
- Additional Outcome
- PFS , DFS Measures of effect HR, OR
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Aspartate Aminotransferases; Colorectal Neoplasms; Humans; Liver Neoplasms; Lymphocytes; Prognosis
- Contact
- Lingling Lu [email protected]
- Organisational Affiliation
- Fujian Medical University
- Funding Source
- the 900th hospital of the Joint Logistics Support Force Fund Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> 2020Z12
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-04-19
- Registration Date
- 2022-05-10
- Anticipated Start Date
- 2022-06-01
- Anticipated Completion Date
- 2022-11-01
- Title Cn
- 天冬氨酸转氨酶-淋巴细胞比值指数（ALRI）在结直肠癌患者中的预后作用
- Title En
- Prognostic role of aspartate aminotransferase-lymphocyte ratio index (ALRI) in patients with colorectal cancer
- Bilingual Status
- complete