Meta AnalysisID 1409
门冬酰胺酶诱发胰腺炎的危险因素：系统评价与Meta分析
CRD42015020265
1. What are the risk factors for developing asparaginase induced associated pancreatitis? 2. Are there factors that protect patients from developing asparaginase induced associated pancreatitis? 3. Is the combination of
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 1409
- Evidence Id
- 9967
- Core Evidence Id
- 9967
- Source Meta Analysis Id
- 1364
- Herb2 Meta Analysis Id
- HBMA001364
- Crd Id
- CRD42015020265
- Title
- Risk factors for asparaginase-induced pancreatitis: a systematic review and meta-analysis
- Review Question
- 1. What are the risk factors for developing asparaginase induced associated pancreatitis? 2. Are there factors that protect patients from developing asparaginase induced associated pancreatitis? 3. Is the combination of a high-dose steroid with asparaginase associated with increased risk of pancreatic ablation?
- Study Type Included
- We will include randomized control trials, controlled clinical trials and observational studies with at least 10 patients that developed asparaginase-associated. These studies must discuss investigated potential risk or protective factors for the development of asparaginase associated pancreatitis. The timeframe of studies will be on or before the year 1966
- Condition Being Studied
- Acute pancreatitis is a painful, inflammatory disorder with multiple etiologies including medications. There are a few medications that are definite causes of acute pancreatitis, and asparaginase is a prime example. Asparaginase is a bacterially derived enzyme that is an important component of all chemotherapeutic regimens for acute lymphoblastic leukemia, the most common childhood cancer. It causes pancreatitis in 16-18% of its users and is classified as a Class I medication on the drug-induced acute pancreatitis scoring system (Trivedi, Pitchumoni, 2005). Information on the risk factors, clinical course and presentation of asparaginase pancreatitis has been poorly reported to date.
- Participant
- Inclusion Criteria: Humans, less than or equal to 18 years of age, participants in acute pancreatitis study group(s) meet criteria for acute pancreatitis diagnosis (Patient must have 2 of the 3 following: (1) classic abdominal pain (2) radiographic evidence of acute pancreatitis (3) elevation of amylase and/or lipase three times the upper limit of normal.) Exclusion Criteria: Non-human participants, Patients that developed pancreatitis before receiving asparaginase, patients in acute pancreatitis study group(s) do not meet criteria for diagnosis of acute pancreatitis
- Animal
- Human Disease Modelled
- Intervention
- We will review clinical risk factors such as age, gender, ALL risk stratification, type of asparaginase used, and concomitant steroid use. Other risk factors will be collected by screening the literature.
- Comparator Control
- Study groups on different types of asparaginase or comparative group that did not develop pancreatitis while on asparaginase.
- Main Outcome
- Risk factors for asparaginase pancreatitis
- Outcome Measure
- Additional Outcome
- Protective factors for asparaginase pancreatitis Potential for increased risk of pancreatitis while on both high-dose steroids and asparaginase.
- Study Method
- Keyword
- Asparaginase; Humans; Pancreatitis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors
- Contact
- Dr Oparaji [email protected]
- Organisational Affiliation
- Children's Hospital of Pittsburgh www.chp.edu
- Funding Source
- Children''s Hospital of Pittsburgh, Department of Pediatric Gastroenterology
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- United States of America
- Review Stage
- Review Ongoing
- First Submission Date
- Registration Date
- 2015-05-13
- Anticipated Start Date
- 2015-04-27
- Anticipated Completion Date
- 2015-12-31
- Title Cn
- 门冬酰胺酶诱发胰腺炎的危险因素：系统评价与Meta分析
- Title En
- Risk factors for asparaginase-induced pancreatitis: a systematic review and meta-analysis
- Bilingual Status
- complete