Meta AnalysisID 1403
青蒿素类和奎宁类治疗妊娠期无并发症恶性疟疾的疗效：系统评价与个体患者数据（IPD）Meta分析
CRD42018104013
To describe the efficacy of quinine-based and artemisinin-based treatment used to treat uncomplicated falciparum malaria during pregnancy and to identify the risk factors of treatment failure
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Record Fields
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- Meta Analysis Id
- 1403
- Evidence Id
- 9961
- Core Evidence Id
- 9961
- Source Meta Analysis Id
- 1358
- Herb2 Meta Analysis Id
- HBMA001358
- Crd Id
- CRD42018104013
- Title
- The efficacy of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: a systematic review and individual patient data (IPD) meta-analysis
- Review Question
- To describe the efficacy of quinine-based and artemisinin-based treatment used to treat uncomplicated falciparum malaria during pregnancy and to identify the risk factors of treatment failure
- Study Type Included
- We will include studies which prospectively and actively followed up patients for clinical and parasitological assessment for at least 28 days. Randomised control trials, interventional and observational cohort studies that used PCR for recurrence of falciparum malaria will be included.
- Condition Being Studied
- Falciparum malaria, treatment efficacy, pregnancy
- Participant
- Inclusion: pregnant women with microscopically confirmed falciparum malaria who were treated with quinine-based or artemisinin-based treatment irrespective of trimesters and symptoms. Exclusion: Non-pregnant patients. Patients who were diagnosed clinically without confirmation by microscopy. Patients without information on parasitaemia load on day 0.
- Animal
- Human Disease Modelled
- Intervention
- Artemisinin-based treatment artemether-lumefantrine (AL) artesunate + amodiaquine (ASAQ) artesunate + mefloquine (ASMQ) artesunate + sulfadoxine-pyrimethamine (ASSP) dihydroartemisinin-piperaquine (DP) artesunate + atovaquone-proguanil artesunate + clindamycin artesunate monotherapy artemether monotherapy Quinine-based treatment quinine monotherapy quinine + clindamycin
- Comparator Control
- Interventions specified above will be compared.
- Main Outcome
- Treatment failure defined by WHO for non-pregnant population Measures of effect on day 28, 42, 63 and at delivery recurrences tested by PCR
- Outcome Measure
- Additional Outcome
- Parasite clearance Gametocyte carriage Adverse symptoms Pregnancy outcomes Measures of effect Parasite clearance : on day1, 2, 3 by microscopy Gametocyte carriage : on day 7, 14, 21, 28 by microscopy Adverse symptoms : developed in the first week after the treatment by clinical assessment Pregnancy outcomes: at delivery by clinical assessment
- Study Method
- Individual patient data (IPD) meta-analysis, Systematic review
- Keyword
- Antimalarials; Artemisinins; Female; Humans; Malaria, Falciparum; Pregnancy; Quinine; artemisinine
- Contact
- Makoto Saito [email protected]
- Organisational Affiliation
- WorldWide Antimalarial Resistance Network http://www.wwarn.org/
- Funding Source
- The WorldWide Antimalarial Resistance Network is funded by Bill and Melinda Gates Foundation and the ExxonMobil Foundation.
- Other Selection Criteria
- Final Publication
- Saito, Makoto et al. Efficacy and tolerability of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: a systematic review and individual patient data meta-analysis.The Lancet Infectious Diseases, Volume 20, Issue 8, 943 - 952 Saito, M., Mansoor, R., Kennon, K. et al. Pregnancy outcomes and risk of placental malaria after artemisinin-based and quinine-based treatment for uncomplicated falciparum malaria in pregnancy: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis. BMC Med 18, 138 (2020). https://doi.org/10.1016/S1473-3099(20)30064-5
- Same Topic Review
- Published Protocol
- https://doi.org/10.1136/bmjopen-2018-027503
- Review Type
- Language
- English
- Country
- England, Thailand
- Review Stage
- Review Completed published
- First Submission Date
- Registration Date
- 2018-07-31
- Anticipated Start Date
- 2016-07-05
- Anticipated Completion Date
- 2019-09-30
- Title Cn
- 青蒿素类和奎宁类治疗妊娠期无并发症恶性疟疾的疗效：系统评价与个体患者数据（IPD）Meta分析
- Title En
- The efficacy of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: a systematic review and individual patient data (IPD) meta-analysis
- Bilingual Status
- complete