Meta AnalysisID 1396
奎宁类和青蒿素类治疗妊娠期（所有孕期）无并发症恶性疟疗效的系统文献综述及方法评估
CRD42017054808
To describe the efficacy of quinine-based and artemisinin-based treatment used to treat uncomplicated falciparum malaria during pregnancy (all trimesters). To describe the methodology of assessing the efficacy of quinine
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Record Fields
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- Meta Analysis Id
- 1396
- Evidence Id
- 9954
- Core Evidence Id
- 9954
- Source Meta Analysis Id
- 1353
- Herb2 Meta Analysis Id
- HBMA001353
- Crd Id
- CRD42017054808
- Title
- A systematic literature review of the efficacy of quinine-based and artemisinin-based treatment for uncomplicated falciparum malaria during pregnancy (all trimesters) and assessment of methods
- Review Question
- To describe the efficacy of quinine-based and artemisinin-based treatment used to treat uncomplicated falciparum malaria during pregnancy (all trimesters). To describe the methodology of assessing the efficacy of quinine-based and artemisinin-based treatment in pregnancy
- Study Type Included
- We will include studies which prospectively and actively followed up patients for clinical and parasitological assessment reporting efficacy of the treatment.Randomised control trials, interventional and observational cohort studies will be included.
- Condition Being Studied
- Falciparum malaria, treatment efficacy, pregnancy
- Participant
- Inclusion: pregnant women with parasitologically confirmed falciparum malaria who were treated with quinine-based or artemisinin-based treatment irrespective of trimesters and symptoms. Exclusion: Non-pregnant patients. Patients who were diagnosed clinically without parasitological confirmation.
- Animal
- Human Disease Modelled
- Intervention
- Artemisinin-based treatment artemether-lumefantrine (AL) artesunate + amodiaquine (ASAQ) artesunate + mefloquine (ASMQ) artesunate + sulfadoxine-pyrimethamine (ASSP) dihydroartemisinin-piperaquine (DP) artesunate + atovaquone-proguanil artesunate + clindamycin artesunate monotherapy artemether monotherapy Quinine-based treatment quinine monotherapy quinine + clindamycin
- Comparator Control
- Interventions specified above will be compared.
- Main Outcome
- Treatment failure defined by WHO for non-pregnant population on day 28, 42, 63 and at delivery. The methodologies used for the efficacy assessment.
- Outcome Measure
- Additional Outcome
- Pregnancy outcomes. The methodologies used for the assessment of pregnancy-related variables and outcomes.
- Study Method
- Systematic review
- Keyword
- Antimalarials; Artemisinins; Female; Humans; Malaria, Falciparum; Pregnancy; Pregnancy Trimesters; Quinine
- Contact
- Dr Saito [email protected]
- Organisational Affiliation
- WorldWide Antimalarial Resistance Network (WWARN), Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford http://www.wwarn.org
- Funding Source
- None.
- Other Selection Criteria
- Final Publication
- - Saito M, Gilder ME, Nosten F, McGready R, Guérin PJ. Systematic literature review and meta-analysis of the efficacy of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: methodological challenges. Malar J. 2017;16:488. - Saito M, Gilder ME, Nosten F, Guérin PJ, McGready R. Methodology of assessment and reporting of safety in anti-malarial treatment efficacy studies of uncomplicated falciparum malaria in pregnancy: a systematic literature review. Malar J. 2017;16:491. http://rdcu.be/CFmo
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- England, Thailand
- Review Stage
- Review Completed published
- First Submission Date
- 2017-11-21
- Registration Date
- 2017-01-09
- Anticipated Start Date
- 2016-07-04
- Anticipated Completion Date
- 2017-02-28
- Title Cn
- 奎宁类和青蒿素类治疗妊娠期（所有孕期）无并发症恶性疟疗效的系统文献综述及方法评估
- Title En
- A systematic literature review of the efficacy of quinine-based and artemisinin-based treatment for uncomplicated falciparum malaria during pregnancy (all trimesters) and assessment of methods
- Bilingual Status
- complete