Meta AnalysisID 1361
大黄治疗动物糖尿病肾病的效果：一项系统评价和Meta分析
CRD42020204701
（1）Dose rhubarb could improve animal models (rats and mice) with diabetic nephropathy? （2）What mechanism does rhubarb affect to improve animal models with diabetic nephropathy? （3）What is the ingredient that rhubarb play
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Record Fields
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- Meta Analysis Id
- 1361
- Evidence Id
- 9919
- Core Evidence Id
- 9919
- Source Meta Analysis Id
- 1319
- Herb2 Meta Analysis Id
- HBMA001319
- Crd Id
- CRD42020204701
- Title
- The effect of rhubarb for the treatment of diabetic nephropathy in animals：a systematic review and meta-analysis
- Review Question
- （1）Dose rhubarb could improve animal models (rats and mice) with diabetic nephropathy? （2）What mechanism does rhubarb affect to improve animal models with diabetic nephropathy? （3）What is the ingredient that rhubarb plays an significant role in improving animal models with diabetic nephropathy? Context and rationale Rhubarb is a traditional Chinese medicine and often used as a laxative in the past. Recently, multiple studies have applied rhubarb to treat diabetic nephropathy (DN). Anthraquinones including emodin and rhein have been extracted from rhubarb and used to explore the effective components and mechanism of rhubarb for DN. Evaluating the efficacy of rhubarb may provide a scientific reference for the clinical application of rhubarb for the treatment of DN.
- Study Type Included
- Inclusion criteria: controlled studies with a separate control group Exclusion criteria: cross-over studies, case report, studies without a separate control group.
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: The diabetic nephropathy animal model (rats or mice, regardless of gender, weight, modeling method) was induced to meet the standard of diabetic nephropathy, blood glucose ≥ 16.65 mmol / L Exclusion criteria: Other animal models except rats and mice (eg. patients, in vitro cells, rabbits, dogs and other animal models)
- Human Disease Modelled
- diabetic nephropathy
- Intervention
- Inclusion criteria: Rhubarb (including rhubarb, emodin and rhein) was given by gavage, with unlimited administration time, frequency and dose Exclusion criteria: Animals with rhubarb compound treatment , or rhubarb was administrated in other ways (such as intravenous injection or intraperitoneal injection)
- Comparator Control
- Inclusion criteria: Vehicle-treated animals, sham-treated animals(saline or distilled water), animals undergoing no treatment Exclusion criteria: Animals with western medicine, other traditional Chinese medicine or integrated Chinese and Western medicine
- Main Outcome
- Outcome Measure
- Inclusion criteria: Glucose, HbA1c, serum creatinine, blood urea nitrogen, albumin creatinine ratio, 24h urine protein, urinary albumin excretion, kidney index,(two kidneys weight/body weight), tubulointerstitial injury index, TGF-β1, α-SMA， E-cad, podocin, nephrin mRNA and protein Exclusion criteria: Kidney index( one kidney weight/body weight)
- Additional Outcome
- Study Method
- Keyword
- Animals; Diabetic Nephropathies; Rheum
- Contact
- Bao Xiaorong [email protected]
- Organisational Affiliation
- Jinshan Hospital, Fudan University https://www.jinshanhos.org.cn/
- Funding Source
- Other Selection Criteria
- Inclusion criteria: Randomized controlled trais.Publication date: From the establishment of the database to August 2020. Language：Chinese and English Exclusion criteria: Semi randomized or non randomized controlled trials, review, meta analysis, patent,
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Pre-clinical animal intervention review
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-08-17
- Registration Date
- 2020-09-30
- Anticipated Start Date
- 2020-08-01
- Anticipated Completion Date
- 2020-10-01
- Title Cn
- 大黄治疗动物糖尿病肾病的效果：一项系统评价和Meta分析
- Title En
- The effect of rhubarb for the treatment of diabetic nephropathy in animals：a systematic review and meta-analysis
- Bilingual Status
- complete