Meta AnalysisID 1354
凝血酶-抗凝血酶复合物对弥散性血管内凝血的诊断价值：一项Meta分析
CRD42022341979
The role of the thrombin-antithrombin complex (TAT) in predicting disseminated intravascular coagulation (DIC) has not been ascertained. Can we use the thrombin-antithrombin complex to diagnose disseminated intravascular
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Record Fields
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- Meta Analysis Id
- 1354
- Evidence Id
- 9912
- Core Evidence Id
- 9912
- Source Meta Analysis Id
- 1313
- Herb2 Meta Analysis Id
- HBMA001313
- Crd Id
- CRD42022341979
- Title
- Diagnostic value of thrombin-antithrombin complex for disseminated intravascular coagulation: a meta-analysis
- Review Question
- The role of the thrombin-antithrombin complex (TAT) in predicting disseminated intravascular coagulation (DIC) has not been ascertained. Can we use the thrombin-antithrombin complex to diagnose disseminated intravascular coagulation? In this meta-analysis, we tend to determine the diagnostic accuracy of the thrombin-antithrombin complex for DIC patients.
- Study Type Included
- Diagnostic trials will be included.
- Condition Being Studied
- Disseminated intravascular coagulation is an acquired disorder that occurs in a wide variety of clinical conditions. All microorganisms can virtually cause disseminated intravascular coagulation, bacterial infection is most frequently related to the development of the syndrome. TAT is a sensitive complex formed by the combination of thrombin and antithrombin. In patients with a venous prothrombotic state, serum TAT levels are abnormally elevated, reflecting the changes in the body's coagulation system when it is activated. TAT test has obvious advantages of simple operation and high efficiency. It is the best choice for doctors to carry out clinical diagnoses. However, the conclusion that TAT can be used as a diagnostic marker of DIC is not clear. Therefore, this study discussed the diagnostic value of TAT in DIC.
- Participant
- Inclusion: (1) Aged 18 or older; (2) The diagnostic value of TAT must be described to ensure that we can directly or indirectly extract or calculate key indicators, including sensitivity, specificity, true positive (TP) value, false positive (FP) value, false negative (FN) value, and true negative (TN) value; (3) The diagnosis of VTE must be based on accepted guidelines; (4) The literature should be written in English or Chinese. Exclusion criteria are defined as follows: (1) Meta-analysis, systematic evaluation, case review, case report, and letter; (2) Exclude articles from non-human studies.
- Animal
- Human Disease Modelled
- Intervention
- As a meta-analysis of diagnostic tests, interventions can be defined as the diagnostic value of the thrombin-antithrombin complex for disseminated intravascular coagulation.
- Comparator Control
- Patients with non-DIC.
- Main Outcome
- The main research indicators are the sensitivity and specificity of diagnostic trials. Measures of effect The pooled sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the summary receiver operating characteristic curve (AUC)
- Outcome Measure
- Additional Outcome
- Study Method
- Diagnostic, Systematic review
- Keyword
- Antithrombin III; Disseminated Intravascular Coagulation; Humans; Peptide Hydrolases; antithrombin III-protease complex
- Contact
- Shuhan Liu [email protected]
- Organisational Affiliation
- Guangzhou University of Chinese Medicine
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-06-24
- Registration Date
- 2022-07-05
- Anticipated Start Date
- 2022-06-01
- Anticipated Completion Date
- 2022-09-01
- Title Cn
- 凝血酶-抗凝血酶复合物对弥散性血管内凝血的诊断价值：一项Meta分析
- Title En
- Diagnostic value of thrombin-antithrombin complex for disseminated intravascular coagulation: a meta-analysis
- Bilingual Status
- complete