Meta AnalysisID 1353
凝血酶-抗凝血酶复合物对静脉血栓栓塞症的诊断价值：一项Meta分析
CRD42022336593
The role of the thrombin-antithrombin complex (TAT) in predicting venous thromboembolism (VTE) has not been ascertained. Can we use the thrombin-antithrombin complex to diagnose venous thromboembolism? In this meta-analy
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 1353
- Evidence Id
- 9911
- Core Evidence Id
- 9911
- Source Meta Analysis Id
- 1312
- Herb2 Meta Analysis Id
- HBMA001312
- Crd Id
- CRD42022336593
- Title
- Diagnostic value of thrombin-antithrombin complex for venous thromboembolism: a meta-analysis
- Review Question
- The role of the thrombin-antithrombin complex (TAT) in predicting venous thromboembolism (VTE) has not been ascertained. Can we use the thrombin-antithrombin complex to diagnose venous thromboembolism? In this meta-analysis, we tend to determine the diagnostic accuracy of the thrombin-antithrombin complex for VTE patients.
- Study Type Included
- Diagnostic trials will be included.
- Condition Being Studied
- VTE refers to the abnormal clotting of blood in the venous lumen, completely or incompletely blocking the venous blood vessels, leading to a circulatory disease of the venous return disorder, including deep vein thrombosis (DVT) and pulmonary artery thromboembolism (PTE), is also a common serious complication in hospitalized patients. TAT is a sensitive complex formed by the combination of thrombin and antithrombin. In patients with a venous prothrombotic state, serum TAT levels are abnormally elevated, reflecting the changes in the body's coagulation system when it is activated. TAT test has obvious advantages of simple operation and high efficiency. It is the best choice for doctors to carry out clinical diagnoses. However, the conclusion that TAT can be used as a diagnostic marker of VTE is not clear. Therefore, this study discussed the diagnostic value of TAT in VTE.
- Participant
- Inclusion: (1) Aged 18 or older; (2) The diagnostic value of TAT must be described to ensure that we can directly or indirectly extract or calculate key indicators, including sensitivity, specificity, true positive (TP) value, false positive (FP) value, false negative (FN) value, and true negative (TN) value; (3) The diagnosis of VTE must be based on accepted guidelines; (4) The literature should be written in English or Chinese. Exclusion criteria are defined as follows: (1) Meta-analysis, systematic evaluation, case review, case report, letter; (2) Exclude articles from non-human studies.
- Animal
- Human Disease Modelled
- Intervention
- As a meta-analysis of diagnostic tests, interventions can be defined as the diagnostic value of thrombin-antithrombin complex for venous thromboembolism.
- Comparator Control
- Patients with non-VTE.
- Main Outcome
- The main research indicators are the sensitivity and specificity of diagnostic trials. Measures of effect Pooled sensitivity and pooled specificity, diagnostic odds ratio, the area under ROC curve, positive likelihood ratio, and negative likelihood ratio.
- Outcome Measure
- Additional Outcome
- None.
- Study Method
- Diagnostic, Systematic review
- Keyword
- Antithrombin III; Humans; Peptide Hydrolases; Venous Thromboembolism; antithrombin III-protease complex
- Contact
- Shuhan Liu [email protected]
- Organisational Affiliation
- Guangzhou University of Chinese Medicine
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-05-31
- Registration Date
- 2022-06-12
- Anticipated Start Date
- 2022-05-01
- Anticipated Completion Date
- 2022-08-01
- Title Cn
- 凝血酶-抗凝血酶复合物对静脉血栓栓塞症的诊断价值：一项Meta分析
- Title En
- Diagnostic value of thrombin-antithrombin complex for venous thromboembolism: a meta-analysis
- Bilingual Status
- complete