Meta AnalysisID 1347
富含花青素的水果对健康中老年人认知功能和大脑健康的影响
CRD42021228007
Can anthocyanin-rich fruits improve cognitive function and brain health of healthy middle-aged and older adults?
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 1347
- Evidence Id
- 9905
- Core Evidence Id
- 9905
- Source Meta Analysis Id
- 1307
- Herb2 Meta Analysis Id
- HBMA001307
- Crd Id
- CRD42021228007
- Title
- Effects of Anthocyanin-rich Fruits on Cognitive Function and Brain Health of Healthy Middle-aged and Older Adults.
- Review Question
- Can anthocyanin-rich fruits improve cognitive function and brain health of healthy middle-aged and older adults?
- Study Type Included
- Include: 1) human randomised controlled trials (RCTs), parallel or crossover design 2) acute or chronic trials 3) unpublished and published trials 4) provide sufficient data to calculate effect size(s) 5) written in English Exclude: 1) Clinical controlled trials (CCTs) 2) One-group pretest post-test design 3) Non-experimental studies 4) Qualitative studies
- Condition Being Studied
- Cognitive enhancement and/or neuroprotective effects of anthocyanin-rich fruits.
- Participant
- Cognitively healthy, independently living middle-aged and older adults aged 40 years and above.
- Animal
- Human Disease Modelled
- Intervention
- Dietary-based interventions that contain anthocyanin-rich fruits will be included. The interventions can be of any forms including fresh fruits, beverages, nutraceutical supplements or extracts. Seven types of fruits with rich anthocyanin content will be included: blackberries, black currants, blueberries, grapes, strawberries, cherries, and plums.
- Comparator Control
- Placebo and/or control groups that receive dietary supplementations containing negligible amounts of anthocyanins.
- Main Outcome
- Differences in post-intervention cognitive performance objectively measured by standardised cognitive tests between intervention and control group. Measures of effect Risk ratios will be calculated for post-intervention cognitive tests that produce dichotomous data. Mean (M) and standard deviation (SD) will be calculated from post-intervention cognitive tests that produce continuous data.
- Outcome Measure
- Additional Outcome
- 1) Differences in post-intervention cerebral blood flow (CBF) measured by neuroimaging between intervention and control group. 2) Differences in post-intervention serum Brain-derived neurotrophic factor (BDNF) concentrations through blood analysis between intervention and control group Measures of effect Mean (M) and standard deviation (SD) will be used to evaluated the post-intervention effects on cerebral blood flow (CBF) and serum Brain-derived neurotrophic factor (BDNF) concentrations.
- Study Method
- Intervention, Meta-analysis, Narrative synthesis, Systematic review
- Keyword
- Aged; Aging; Anthocyanins; Brain; Cognition; Fruit; Humans; Middle Aged
- Contact
- Ruochen Feng [email protected]
- Organisational Affiliation
- Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore https://medicine.nus.edu.sg/nursing/
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Singapore
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-01-06
- Registration Date
- 2021-02-05
- Anticipated Start Date
- 2020-09-07
- Anticipated Completion Date
- 2021-03-08
- Title Cn
- 富含花青素的水果对健康中老年人认知功能和大脑健康的影响
- Title En
- Effects of Anthocyanin-rich Fruits on Cognitive Function and Brain Health of Healthy Middle-aged and Older Adults.
- Bilingual Status
- complete