Meta AnalysisID 1346
矢车菊素-3-O-葡萄糖苷对最常见癌症类型的影响：系统评价
CRD42023390395
Main question: does cyanidin 3-O-glucoside, a flavonoid anthocyanin, have preventive and/or therapeutic effects on the five most frequent types of cancer (breast, lung, colorectal, prostate, and stomach)? Specific questi
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 1346
- Evidence Id
- 9904
- Core Evidence Id
- 9904
- Source Meta Analysis Id
- 1306
- Herb2 Meta Analysis Id
- HBMA001306
- Crd Id
- CRD42023390395
- Title
- The impact of cyanidin 3-O-glucoside on the most common types of cancer: a systematic review
- Review Question
- Main question: does cyanidin 3-O-glucoside, a flavonoid anthocyanin, have preventive and/or therapeutic effects on the five most frequent types of cancer (breast, lung, colorectal, prostate, and stomach)? Specific questions: (a) which cyanidin 3-O-glucoside-containing products (fruits, vegetables, isolated/purified compound, mixtures containing the compound) are more frequently effective against breast, lung, colorectal, prostate, and stomach cancers? (b) which dosages of cyanidin 3-O-glucoside are more frequently effective against breast, lung, colorectal, prostate, and stomach cancers? (c) which anticancer effects are more frequently observed as a consequence of cyanidin 3-O-glucoside consumption or treatment? (d) cyanidin 3-O-glucoside has shown more benefits in which type of cancer (breast, lung, colorectal, prostate, or stomach)?
- Study Type Included
- Types of study to be included: (a) experimental/interventional studies in vitro, with animals, and humans; and (b) observational/cohort studies. There will be no restrictions regarding the type of clinical trial, if randomized controlled or not.
- Condition Being Studied
- Cancer is a chronic disease characterized by abnormal cell proliferation and differentiation and by a high disturbance of cellular mechanisms such as apoptosis, cell-division cycle, inflammation, and oxidative stress. It is the leading cause of death worldwide and its incidence has grown tremendously in the last decades. The five most frequent types of cancer globally, in descending order, are breast, lung, colorectal, prostate, and stomach, which count for almost 50% of all cancer deaths. Although progress has been made regarding the management of cancer, patients still experience the adverse effects of different treatment options as well as chemotherapy resistance and failure.
- Participant
- Four approaches will be included, as follows: (a) in vitro cell lines of breast, lung, colorectal, prostate, and stomach cancers; (b) animal models of breast, lung, colorectal, prostate, and stomach cancers; (c) clinical trials with humans having breast, lung, colorectal, prostate, and stomach cancers; and (d) humans in observational studies, where cyanidin 3-O-glucoside consumption and the circulating levels of cyanidin 3-O-glucoside have been associated with the prevention of breast, lung, colorectal, prostate, and stomach cancers. No restrictions will be considered regarding the characteristics of the population from clinical trials (time of cancer diagnosis, gender, age, among others). Additionally, not only carcinoma but also previous phases of cancer development (e.g., adenoma) will be considered for this review in all populations studied (in vitro, animals, humans).
- Animal
- Human Disease Modelled
- Intervention
- Cyanidin 3-O-glucoside is the most common anthocyanin found in nature. It mostly occurs in fruits and vegetables with pink, red, blue, purple, and/or black pigmentation. Anthocyanins are types of flavonoids, which are part of the large group of phenolic compounds. These compounds have various beneficial effects on health, including antioxidant, anti-inflammatory, and anticancer. For this review, three types of interventions will be searched: (a) fruits and vegetables containing cyanidin 3-O-glucoside; (b) isolated or purified cyanidin 3-O-glucoside; and (c) mixtures of products containing cyanidin 3-O-glucoside; and d) circulating levels or consumption reports of cyanidin 3-O-glucoside through observational studies. Studies that did not quantify the amount of cyanidin 3-O-glucoside in their tested food sources (when applicable) will not be considered. Additionally, studies not discussing the probable mechanism(s) behind the effects of cyanidin 3-O-glucoside or its food sources on cancer will be discarded, according to the search strategy and eligibity.
- Comparator Control
- The experimental or observational groups with cancer (breast, lung, colorectal, prostate, and stomach) that consumed or were treated with cyanidin-3-O-glucoside will be compared with the ones without intervention (control/disease group).
- Main Outcome
- The following outcomes will be searched within the effects of cyanidin-3-O-glucoside on the five most common types of cancer. From observational studies: (a) incidence of cancer; (b) mortality risk; (c) overall survival; (d) cyanidin-3-O-glucoside concentration in blood and/or tissue; and (e) levels of cancer-related proteins/markers on blood and/or tissue. From experimental studies (in vitro, animals, humans): (a) clinical-related parameters in blood or tissue; (b) anti-proliferative effects and viability of cancer cells; (c) proapoptotic effects and related proteins (e.g., caspases, Bcl-2 family of proteins); (d) cell cycle regulatory effects; (e) anti-angiogenic effects (e.g., VEGF-targeting implications); (f) antioxidant-related effects (e.g., reactive oxygen species, antioxidant enzymes); (g) anti-inflammatory-related effects (cytokines, NF-κB-related pathways); (h) anti-metastasis effects; (i) anti-dysbiotic/microbiota-related effects; and (j) among other cancer-related outcomes that judged relevant. Measures of effect The main effects included will be hazard risk and odds ratio.
- Outcome Measure
- Additional Outcome
- Not applicable. Measures of effect Not applicable.
- Study Method
- Systematic review
- Keyword
- Anthocyanins; Colorectal Neoplasms; Flavonoids; Fruit; Glucosides; Humans; Male; Prostate; Prostatic Neoplasms; Stomach; Vegetables; cyanidin
- Contact
- Roberto de Paula do Nascimento [email protected]
- Organisational Affiliation
- Cardiff University; University of Campinas; Virgen de la Victoria University Hospital; Instituto de Salud Carlos III; Reina Sofia University Hospital https://www.cardiff.ac.uk/; https://www.unicamp.br/unicamp/; https://www.huvv.es/; https://www.isciii.es/Paginas/Inicio.aspx; https://www.sspa.juntadeandalucia.es/servicioandaluzdesalud/hrs3; https://www.ibima.eu; https://www.imibic.org;
- Funding Source
- Fundação de Amparo à Pesquisa do Estado de São Paulo; IBIMA; EMBO; Instituto de Salud Carlos III Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> 2019/03228-9, 2022/10485-0; Plan Propio IBIMA 2020 A.1, Ref.: predoc20_002; CD22/00053; EMBO Scientific Exchange Grant 9573.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Brazil, Spain, Wales
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-01-11
- Registration Date
- 2023-01-13
- Anticipated Start Date
- 2023-01-20
- Anticipated Completion Date
- 2023-03-20
- Title Cn
- 矢车菊素-3-O-葡萄糖苷对最常见癌症类型的影响：系统评价
- Title En
- The impact of cyanidin 3-O-glucoside on the most common types of cancer: a systematic review
- Bilingual Status
- complete