Meta AnalysisID 1270
草药联合钙剂或维生素D补充治疗原发性骨质疏松症的效果：系统评价与Meta分析
CRD42023390806
Is the combination of herbal medicine with calcium or vitamin D supplements more effective in improving bone mineral density in patients with primary osteoporosis than calcium or vitamin D supplements alone?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 1270
- Evidence Id
- 9828
- Core Evidence Id
- 9828
- Source Meta Analysis Id
- 1233
- Herb2 Meta Analysis Id
- HBMA001233
- Crd Id
- CRD42023390806
- Title
- Combination effects of herbal medicine with calcium or vitamin D supplements for primary osteoporosis: a systematic review and meta-analysis.
- Review Question
- Is the combination of herbal medicine with calcium or vitamin D supplements more effective in improving bone mineral density in patients with primary osteoporosis than calcium or vitamin D supplements alone?
- Study Type Included
- must be RCTs
- Condition Being Studied
- Osteoporosis is a systemic skeletal disease characterized by low bone mass and micro architectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture by World Health Organization (WHO). The socioeconomic burden caused by osteoporosis is at a serious level. Calcium and vitamin D have been widely used as supplements that play an important role in the prevention and treatment of osteoporosis. However, several studies have reported in recent years that calcium and vitamin D have little efficacy in lowering the risk of fractures in osteoporosis. Meanwhile, there are studies showing that herbal medicine had a significant effect on improving BMD in osteoporosis patients. From this point of view, this author thought that for patients with primary osteoporosis, taking herbal medicine and supplements together would have the effect of improving BMD more significantly than a single dose of supplement. Many previous studies analyzed the effects of taking herbal medicine and supplements in combination with osteoporosis, but there have been no studies that have reviewed and systematically analyzed the studies so far.
- Participant
- Patients with primary osteoporosis by the diagnostic criteria of the WHO in 1994
- Animal
- Human Disease Modelled
- Intervention
- herbal medicine combined with supplements(calcium or vitamin D) orally taken
- Comparator Control
- supplements(calcium or vitamin D) only
- Main Outcome
- BMD score measured by DXA Measures of effect mean differnces
- Outcome Measure
- Additional Outcome
- If possible, the following will be reviewed: 1) bone turnover markers -bone formation markers (ex. OC, P1NP...) -bone resorption markers (ex. TRACP, CTX...) -bone mineral markers (ex. Ca, P...) -hormone (ex. E2...) 2) herbal medicine used frequently for primary osteoporosis 3) prescription pattern of herbal medicine -liver-kidney yin deficiency pattern -kidney yang deficiency pattern -syndrome of qi stagnation and blood stasis 4) adverse effects
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Calcium, Dietary; Humans; Minerals; Osteoporosis; Vitamin D; Vitamins
- Contact
- Hee-Joo Park [email protected]
- Organisational Affiliation
- College of Korean Medicine, Daejeon University, 75, Daedeokdae-ro 176, Seo-gu, Daejeon 35235, South Korea. https://www.dju.ac.kr/medicine/main.do
- Funding Source
- National Research Foundation of Korea grant funded by the Ministry of Science, ICT & Future Planning (NRF—2021R1A2C2013483) Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> National Research Foundation of Korea grant funded by the Ministry of Science, ICT & Future Planning (NRF—2021R1A2C2013483)
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- South Korea
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-01-17
- Registration Date
- 2023-01-28
- Anticipated Start Date
- 2022-07-06
- Anticipated Completion Date
- 2023-02-22
- Title Cn
- 草药联合钙剂或维生素D补充治疗原发性骨质疏松症的效果：系统评价与Meta分析
- Title En
- Combination effects of herbal medicine with calcium or vitamin D supplements for primary osteoporosis: a systematic review and meta-analysis.
- Bilingual Status
- complete