Meta AnalysisID 1257
磷酸钙基生物材料：添加剂及动物实验性能的系统评价
CRD42022333451
What additives are added to improve the performance of calcium phosphate biomaterials in animal experiments? What common outcome measures are evaluated and reported? Context and rationale Calcium phosphate is a grafting
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Record Fields
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- Meta Analysis Id
- 1257
- Evidence Id
- 9815
- Core Evidence Id
- 9815
- Source Meta Analysis Id
- 1221
- Herb2 Meta Analysis Id
- HBMA001221
- Crd Id
- CRD42022333451
- Title
- Calcium phosphate-based biomaterials: a systematic review of additive and performance on animal experiments
- Review Question
- What additives are added to improve the performance of calcium phosphate biomaterials in animal experiments? What common outcome measures are evaluated and reported? Context and rationale Calcium phosphate is a grafting material that is both bioactive and biodegradable. Due to its superior biological properties, probable resorbability, molding capabilities, and ease of manipulation, this material has been intensively explored. In recent years, this material has had clinical success in a variety of dental and orthopedic applications. Furthermore, certain of its properties, like as injectability or low-temperature setting, which allows the incorporation of various medications, make them particularly appealing candidates. The purpose of this systematic review is to provide a comprehensive overview of the performance of calcium phosphate as a carrier of various additives in animal experiments, including drugs, ions, amino acids and peptides, nucleic acids, and cells.
- Study Type Included
- Inclusion criteria: Randomized or non-randomized controlled animal experimental studies. Exclusion criteria: Letters, commentaries, case reports, reviews, short communications, correspondences, and conference abstracts.
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: Any animal study involving the implatation of calcium phosphate biomaterials with additives. Controlled animal experiments involving experimental group and at least six animals per test group, whether randomized or non-randomized. Exclusion criteria: Ex vivo studies, in-vitro studies, studies in humans. Studies with less than 6 animals per group.
- Human Disease Modelled
- Bone defects that need grafting and reconstruction using bone substitutes.
- Intervention
- Inclusion criteria: Biomaterials based on calcium phosphate with one kind of additive were implanted into animals. No limitation to the observation period was placed. Exclusion criteria: Calcium phosphate without any additives was investigated in studies. Calcium phosphate integrated with more than one additive was investigated.
- Comparator Control
- Inclusion criteria: Animals implanted with calcium phosphate There are no restrictions on the location of implantation. Exclusion criteria: Studies involving fewer than six animals in each control group.
- Main Outcome
- Outcome Measure
- Inclusion criteria: Bibliographic information, kind of base material, type of additive, animal species, strain, animal model, implanted site, observation duration, significant outcome, and conclusion on improvement were among the information collected. Exclusion criteria: None of those indicated above.
- Additional Outcome
- Study Method
- Keyword
- Animal Experimentation; Animals; Biocompatible Materials; Calcium Phosphates; Humans
- Contact
- Xinlin Gao [email protected]
- Organisational Affiliation
- Honghui Hospital, Xi'an Jiaotong University https://www.xahhyy.com/
- Funding Source
- None.
- Other Selection Criteria
- Studies published in languages other than English are excluded.
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Pre-clinical animal intervention review
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-05-18
- Registration Date
- 2022-05-29
- Anticipated Start Date
- 2022-02-01
- Anticipated Completion Date
- 2022-08-31
- Title Cn
- 磷酸钙基生物材料：添加剂及动物实验性能的系统评价
- Title En
- Calcium phosphate-based biomaterials: a systematic review of additive and performance on animal experiments
- Bilingual Status
- complete