Meta AnalysisID 1228
硅酸钙基牙髓封闭剂的生物学性能是否优于AH Plus？系统评价
CRD42022275979
Based on in vivo animal studies and in vitro laboratory studies, premixed calcium silicate-based endodontic sealers have better biological properties compared to AH Plus? Context and rationale Calcium silicate-based sea
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Record Fields
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- Meta Analysis Id
- 1228
- Evidence Id
- 9786
- Core Evidence Id
- 9786
- Source Meta Analysis Id
- 1194
- Herb2 Meta Analysis Id
- HBMA001194
- Crd Id
- CRD42022275979
- Title
- CALCIUM SILICATE-BASED ENDODONTIC SEALERS PRESENT BIOLOGICAL PROPERTIES GREATER THAN AH PLUS? A SYSTEMATC REVIEW
- Review Question
- Based on in vivo animal studies and in vitro laboratory studies, premixed calcium silicate-based endodontic sealers have better biological properties compared to AH Plus? Context and rationale Calcium silicate-based sealers seem to be promising as a material of choice during endodontic treatment due to their biological properties. This study proposes to carry out a systematic literature review, organized according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), with the objective of answering the following research question: “Based on in vivo animal studies and in vitro laboratory studies, premixed calcium silicate-based endodontic sealers have better biological properties compared to AH Plus?”. The results of this research will provide information that may assist the dental surgeon in selecting the best root canal sealer to be used in clinical practice.
- Study Type Included
- Inclusion criteria: Animals and in vitro studies: Cross-sectional studies. Exclusion criteria: Clinical trials, cohort studies, case and control studies.
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: Animals: rats, all strains, all sexes. Exclusion criteria: In silico studies and human studies will be excluded.
- Human Disease Modelled
- Toxicity of endodontic sealers; biocompatibility; citotoxicity; genotoxicity.
- Intervention
- Inclusion criteria: Premixed calcium silicate-based endodontic sealers Exclusion criteria: Calcium silicate-based endodontic sealers not premixed and sealers not calcium silicate-based.
- Comparator Control
- Inclusion criteria: Animals and in vitro studies: Treated with a different intervention (AH Plus sealer). Exclusion criteria: Animals and in vitro studies: All other comparator conditions different of AH Plus sealer (e.g. other conventional endodontic sealer).
- Main Outcome
- Outcome Measure
- Inclusion criteria: Animals: biocompatibility. Cellular: citotoxicity and genotoxicity. Exclusion criteria: Other biological properties (eg, antimicrobial effect, bioactivity, cell migration, cell morphology, cell adhesion, activity of immunological inflammatory biomarkers).
- Additional Outcome
- Study Method
- Keyword
- Animals; Calcium Compounds; Epoxy Resins; Root Canal Filling Materials; Silicates; calcium silicate; epoxy resin-based root canal sealer
- Contact
- Cristiana Malta [email protected]
- Organisational Affiliation
- Universidade Federal de Santa Maria https://www.ufsm.br/
- Funding Source
- Self funded Grant number(s) Not applicable.
- Other Selection Criteria
- Animals and in vitro studies: Inclusion criteria: all languages, all publication dates. Exclusion criteria: none.
- Final Publication
- Same Topic Review
- There are no previous versions .
- Published Protocol
- Review Type
- Experimental animal exposure review
- Language
- English
- Country
- Brazil
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-09-12
- Registration Date
- 2022-02-01
- Anticipated Start Date
- 2021-06-01
- Anticipated Completion Date
- 2022-03-31
- Title Cn
- 硅酸钙基牙髓封闭剂的生物学性能是否优于AH Plus？系统评价
- Title En
- CALCIUM SILICATE-BASED ENDODONTIC SEALERS PRESENT BIOLOGICAL PROPERTIES GREATER THAN AH PLUS? A SYSTEMATC REVIEW
- Bilingual Status
- complete