Meta AnalysisID 1210
负载抗生素的硫酸钙在慢性骨髓炎临床治疗中的应用：系统评价与Meta分析
CRD42022299870
Antibiotic-loaded calcium sulfate in clinical treatment of chronic osteomyelitis. First of all, we will summarize the eradication rate, delayed healing rate, reoperation rate, refracture rate and incidence of aseptic wou
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Record Fields
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- Meta Analysis Id
- 1210
- Evidence Id
- 9768
- Core Evidence Id
- 9768
- Source Meta Analysis Id
- 1176
- Herb2 Meta Analysis Id
- HBMA001176
- Crd Id
- CRD42022299870
- Title
- Antibiotic-loaded calcium sulfate in clinical treatment of chronic osteomyelitis: a systematic review with meta- analysis
- Review Question
- Antibiotic-loaded calcium sulfate in clinical treatment of chronic osteomyelitis. First of all, we will summarize the eradication rate, delayed healing rate, reoperation rate, refracture rate and incidence of aseptic wound leakage of calcium sulfate loaded with antibiotics in the treatment of chronic osteomyelitis. Secondly, we intend to compare the efficacy of loaded tobramycin loaded and vancomycin loaded with gentamicin calcium sulfate in the treatment of chronic osteomyelitis.
- Study Type Included
- Only case series and consecutive case-control studies regarding the clinical application of antibiotic-loaded calcium sulfate in the treatment of chronic osteomyelitis were eligible for inclusion.
- Condition Being Studied
- Chronic osteomyelitis is defined as a significant and long-standing infection of bone tissue, which is evolved more than several months or even years and involved in any bone including periosteum, bone marrow and surrounding tissue. Most infections occur after trauma, surgery or secondary to vascular and neurologic insufficiency (e.g. diabetic foot ulcers), characterized by persistent bacteria, low-grade inflammation, and the prevalence of fistula and dead bone. With the improvement of diagnosis and population aging, chronic osteomyelitis incidence has apparently increased. In 2004, there were approximately 600, 000 artificial joint replacements and 2 million fracture fixation devices implanted each year in the U.S. alone, resulting more than 110, 000 infections finally. According related estimation of research, the treatment of implant-related chronic osteomyelitis will cost $1.62 billion dollars by 2020 in US hospital and impose a substantial financial burden on patients and society. In addition, infected chronic diabetic foot ulcers may lead to diabetic foot osteomyelitis (DFO), which will increase the mortality and risk of amputation. The recurrent and persistent infection is an challenging condition for both the physician and the patient.
- Participant
- Several eligibility criteria were applied in the present study. Only case series and consecutive case-control studies regarding the clinical application of antibiotic-loaded calcium sulfate in the treatment of chronic osteomyelitis were eligible for inclusion, case reports, review articles, meta-analysis, animal researches, or unpublished studies were excluded. Articles written in a language other than English or German were excluded. Publication, studies involving patients with osteomyelitis due to any causative mechanism except diabetic ulcer treatment were eligible for inclusion. In order to be included, the study population had to comprise ≥ five patients and each eligible report had to contain at least one of the outcomes of interest. The primary outcome of interest was eradication rates of infection, but studies that reported influence on bone regeneration, and local complication (wound-healing problems, prolonged wound drainage, aseptic wound leakage, etc.) were also eligible for inclusion. Patient selection was not further restricted on the basis of sex, age, or other patient characteristics.
- Animal
- Human Disease Modelled
- Intervention
- After thorough debridement, biodegradable calcium sulfate loaded with antibiotics was implanted in all patients with chronic osteomyelitis.
- Comparator Control
- Main Outcome
- Eradication rate, delayed healing rate, reoperation rate, refracture rate and incidence of aseptic wound leakage Measures of effect Overall eradication rate, overall delayed healing rate, overall reoperation rate, overall refracture rate and overall incidence of aseptic wound leakage
- Outcome Measure
- Additional Outcome
- We may also need to summarize the results of the pharmacokinetics of antibiotics released by calcium sulfate, as well as the amputation rate and mortality rate.
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Anti-Bacterial Agents; Calcium Sulfate; Humans; Osteomyelitis; Vancomycin
- Contact
- Xiangwen Shi [email protected]
- Organisational Affiliation
- Kunming Medical University https://www.kmmc.cn/
- Funding Source
- This study was funded by Yunnan Traumatology and Orthopedics Clinical Medical Center (ZX20191001); the MIF-based WNT/p38 MAPK/NF-κB Signaling Loop Regulates Differentiation of Osteoblasts, Osteoclasts, and Coupling Under Inflammatory Conditions (81772367); on the Role and Mechanism of Bap/avβ/TLR-4 Signal Regulating Osteogenesis by Osteoblast in Osteomyelitis (82072392). Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> Yunnan Traumatology and Orthopedics Clinical Medical Center (ZX20191001); the MIF-based WNT/p38 MAPK/NF-κB Signaling Loop Regulates Differentiation of Osteoblasts, Osteoclasts, and Coupling Under Inflammatory Conditions (81772367); on the Role and Mechanism of Bap/avβ/TLR-4 Signal Regulating Osteogenesis by Osteoblast in Osteomyelitis (82072392).
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-01-03
- Registration Date
- 2022-02-17
- Anticipated Start Date
- 2021-12-22
- Anticipated Completion Date
- 2022-03-19
- Title Cn
- 负载抗生素的硫酸钙在慢性骨髓炎临床治疗中的应用：系统评价与Meta分析
- Title En
- Antibiotic-loaded calcium sulfate in clinical treatment of chronic osteomyelitis: a systematic review with meta- analysis
- Bilingual Status
- complete