Meta AnalysisID 1202
磷酸钙衍生物制剂治疗磨牙-切牙矿化不全的效果——系统评价与Meta分析
CRD42021264202
Is there any reduction in dentine sensitivity and increase in remineralization of the tooth affected with Molar incisor Hypomineralization in children?
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Record Fields
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- Meta Analysis Id
- 1202
- Evidence Id
- 9760
- Core Evidence Id
- 9760
- Source Meta Analysis Id
- 1169
- Herb2 Meta Analysis Id
- HBMA001169
- Crd Id
- CRD42021264202
- Title
- Effect of Calcium Phosphate derivative agents for the treatment of MIH - A systematic review & Meta-Analysis
- Review Question
- Is there any reduction in dentine sensitivity and increase in remineralization of the tooth affected with Molar incisor Hypomineralization in children?
- Study Type Included
- The present review will include controlled clinical trials randomized only that have evaluated the effects of calcium phosphate derivative mineralizing agents for improvement in sensitivity and remineralization of the tooth with MIH in children
- Condition Being Studied
- The term Molar Incisor Hypomineralization (MIH) was introduced in 2001 describing the clinical presence of hypomineralized enamel due to systemic causes typically appearing on one or more first permanent molars. The enamel defects can clinically vary in color from white to yellowish or brown with sharp demarcation between the affected and the sound enamel. The prevalence rate of the condition varies from 3.6% to 37.5%. Defected tooth/ teeth are more susceptible to plaque accumulation and caries. And the condition can affect the incisors also, thus requiring timely diagnosis and dental treatment. The treatment of teeth with MIH can be painful due to difficulties in anaesthetizing, most likely due to subclinical inflammation of the pulpal cells caused by the porosity of the enamel. Because of the difficulties in achieving adequate anesthesia and frequent treatments, children with hypomineralized first molars may show difficult behavior and dental fear and anxiety
- Participant
- Children with MIH
- Animal
- Human Disease Modelled
- Intervention
- Any topical formulation of calcium phosphate agent (amorphous calcium phosphate (ACP), casein phosphopeptide-amorphous calcium phosphate (CPP-ACP). There will be no restrictions regarding concentration or duration of the application
- Comparator Control
- The intervention must be compared to no treatment/placebo. We will compare it with intervention not containing any formulation of calcium phosphate agent.
- Main Outcome
- Improvement in dental sensitivity and remineralization of tooth MIH Measures of effect The mean (SD) number of arrested carious tooth surfaces will be assessed. PF (prevented fraction) is the difference in mean caries increment between the control and test groups, divided by the mean increment in the control group, expressed as a percentage. The effect measure used will be the mean difference or standardized mean difference for the results reported as continuous data (mean and SD). We will determine the number of caries lesions at each follow-up to calculate RRs, ORs, and the proportion of individuals/teeth/surfaces developing new caries for dichotomous data.
- Outcome Measure
- Additional Outcome
- Study Method
- Intervention, Systematic review
- Keyword
- Calcium; Calcium Phosphates; Humans
- Contact
- Kusum Singal [email protected]
- Organisational Affiliation
- PGIMER, Chandigarh
- Funding Source
- ICMR Center for Advanced Research in Evidence-Based Child Health, PGIMER, Chandigarh
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- India
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-06-25
- Registration Date
- 2021-07-25
- Anticipated Start Date
- 2021-06-10
- Anticipated Completion Date
- 2021-09-30
- Title Cn
- 磷酸钙衍生物制剂治疗磨牙-切牙矿化不全的效果——系统评价与Meta分析
- Title En
- Effect of Calcium Phosphate derivative agents for the treatment of MIH - A systematic review & Meta-Analysis
- Bilingual Status
- complete