Meta AnalysisID 120
体力活动中薄荷醇的热生理和心血管效应
CRD42019125034
What are the thermophysiological and cardiovascular impacts of menthol application during physical exercise?
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Record Fields
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- Meta Analysis Id
- 120
- Evidence Id
- 8678
- Core Evidence Id
- 8678
- Source Meta Analysis Id
- 107
- Herb2 Meta Analysis Id
- HBMA000107
- Crd Id
- CRD42019125034
- Title
- Thermophysiological and cardiovascular effects of menthol during physical exercise
- Review Question
- What are the thermophysiological and cardiovascular impacts of menthol application during physical exercise?
- Study Type Included
- We will include randomized control trials in which sport performance parameters have been reported in adult subjects with and without application of menthol.
- Condition Being Studied
- Thermophysiological and cardiovascular effects of menthol application in healthy participants in physical exercise.
- Participant
- Healthy, physically active adult men and women.
- Animal
- Human Disease Modelled
- Intervention
- Training with application of menthol.
- Comparator Control
- Training without application of menthol.
- Main Outcome
- Menthol is a known modulator of the cold-activated thermosensory pathway in experimental animals. Human studies also suggest that menthol can reduce cutaneous blood flow and sweating and increase deep body temperature. These thermoregulatory actions of menthol can increase the risk of heat–related illnesses, especially during exposure to internal (physical activity) and/or external (high ambient temperature) heat load. We want to know whether the application of menthol is safe in athletes despite these physiological effects. Since fatal hard endpoints such as heat stroke are rarely used in interventional clinical trials, instead of choosing heat stroke as a specific outcome, we want to study how the thermophysiological and cardiovascular parameters, specifically heart rate, skin temperature, deep body temperature, and sweat production, which can mean risks for heat-related illnesses are affected by menthol in physical exercise (i.e. a form of internal heat stress) in different environmental conditions, also including warmth exposure. Measures of effect None.
- Outcome Measure
- Additional Outcome
- None. Measures of effect Not applicable.
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Athletic Performance; Humans; Menthol
- Contact
- Andras Garami [email protected]
- Organisational Affiliation
- Institute for Translational Medicine, Medical School, University of Pecs www.pte.hu
- Funding Source
- Medical School, University of Pecs; National Research, Development and Innovation Office; and the New National Excellence Program of the Hungarian Ministry of Human Capacities
- Other Selection Criteria
- Final Publication
- Patrik Keringer, Nelli Farkas, Noemi Gede, Peter Hegyi, Zoltan Rumbus, Zsolt Lohinai, Margit Solymar, Kasidid Ruksakiet, Gabor Varga and Andras Garami. Menthol can be safely applied to improve thermal perception during physical exercise: a meta-analysis of randomized controlled trials. Scientific Reports. 2020;10(1):13636. https://doi.org/10.1038/s41598-020-70499-9 https://www.nature.com/articles/s41598-020-70499-9
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Hungary
- Review Stage
- Review Completed published
- First Submission Date
- 2019-03-01
- Registration Date
- 2019-12-02
- Anticipated Start Date
- 2019-01-14
- Anticipated Completion Date
- 2019-12-31
- Title Cn
- 体力活动中薄荷醇的热生理和心血管效应
- Title En
- Thermophysiological and cardiovascular effects of menthol during physical exercise
- Bilingual Status
- complete