ITCMDBv1
DiseaseID 4559

坏死

phenotype

NCI2016_NCI-GLOSS_1602D:Refers to the death of tissues.|NCI2016_CDISC_1602D:Death of a group of cells in an organ or tissue. (INHAND)|NCI2016_02D:Relating to or affected by necrosis.|NCI2016_02D:A cell death process that

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Disease: 1Symptom: 5Target: 12Links: 17
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Record Fields

Scalar fields from the final disease record.

Disease Id
4559
Core Entity Id
60926
Source Entity Count
2
Preferred Name
Necrosis
Name Cn
坏死
Name Pinyin
Huai Si
Name En
Necrosis
Name Latin
Bilingual Status
complete
Disease Type
phenotype
Umls Disease Type
Organ or Tissue Function
Disgenet Type
phenotype
Mesh Class
Pathological Conditions, Signs and Symptoms
Do Class
Hpo Class
Mesh Class Name
Pathological Conditions, Signs and Symptoms
Hpo Class Name
Do Class Name
Disease Definition
NCI2016_NCI-GLOSS_1602D:Refers to the death of tissues.|NCI2016_CDISC_1602D:Death of a group of cells in an organ or tissue. (INHAND)|NCI2016_02D:Relating to or affected by necrosis.|NCI2016_02D:A cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents.|MSH2017_2016_08_12:The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.|GO2016_05_01:OBSOLETE. The processes that cause necrosis, the death of tissues, in another organism. [GOC:ma]|GO2016_05_01:OBSOLETE. A permanent cessation of all vital functions of a tissue. [GOC:dph, GOC:mtg_apoptosis]|GO2016_05_01:A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues. [GOC:mtg_apoptosis, PMID:18846107, PMID:20823910]|CSP2006:sum of the morphological changes indicative of cell death and caused by the progressive degradation action of enzymes; may affect groups of cells or part of a structure or an organ.
Version
v2
Suppressed
No

Names

Preferred names, aliases, and source labels retained in the final schema.

Name
Necrosis
Role
preferred

Cross References

Trusted external identifiers retained for this final record.

Herb
HBDIS002060
Sym Map
SMDE11326
Dis Ge Net
C0027540
Umls Sty
T042
Me Sh Class
C23
Tcmbank Disease
177526869
Itcmdb Generated
ITX-DISEASE-F197924B5639

Attributes

Merged source attributes and domain-specific metadata.

Version
v2
Suppress
0
Disease Type
phenotype
Umls Disease Type
Organ or Tissue Function
Disease Definition
NCI2016_NCI-GLOSS_1602D:Refers to the death of tissues.|NCI2016_CDISC_1602D:Death of a group of cells in an organ or tissue. (INHAND)|NCI2016_02D:Relating to or affected by necrosis.|NCI2016_02D:A cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents.|MSH2017_2016_08_12:The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.|GO2016_05_01:OBSOLETE. The processes that cause necrosis, the death of tissues, in another organism. [GOC:ma]|GO2016_05_01:OBSOLETE. A permanent cessation of all vital functions of a tissue. [GOC:dph, GOC:mtg_apoptosis]|GO2016_05_01:A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues. [GOC:mtg_apoptosis, PMID:18846107, PMID:20823910]|CSP2006:sum of the morphological changes indicative of cell death and caused by the progressive degradation action of enzymes; may affect groups of cells or part of a structure or an organ.
Me Sh Disease Class
Pathological Conditions, Signs and Symptoms
Dis Ge Net Disease Type
phenotype
Disease Class Name Me Sh
Pathological Conditions, Signs and Symptoms
Umls Semantic Type Name
Organ or Tissue Function