DiseaseID 3896

实验性自身免疫性脑脊髓炎

disease

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Disease: 1Symptom: 4Target: 12Links: 16

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Record Fields

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Disease Id: 3896
Core Entity Id: 60161
Source Entity Count: 2
Preferred Name: Experimental Autoimmune Encephalomyelitis
Name Cn: 实验性自身免疫性脑脊髓炎
Name Pinyin: Shi Yan Xing Zi Shen Mian Yi Xing Nao Ji Sui Yan
Name En: Experimental Autoimmune Encephalomyelitis
Name Latin
Bilingual Status: complete
Disease Type: disease
Umls Disease Type: Experimental Model of Disease
Disgenet Type: disease
Mesh Class: Immune System Diseases; Nervous System Diseases
Do Class
Hpo Class
Mesh Class Name: Immune System Diseases; Nervous System Diseases
Hpo Class Name
Do Class Name
Disease Definition: NCI2016_02D:An autoimmune demyelinating disease of the central nervous system that is produced experimentally in animals by the injection of homogenized brain or spinal cord in Freund's adjuvant. Myelin basic protein appears to be the antigen that elicits the hypersensitivity immune response which is characterized by focal areas of lymphocyte and macrophage infiltration into the brain, associated with demyelination and destruction of the blood-brain barrier. Experimental allergic encephalomyelitis (EAE) is used as an animal model for demyelinating diseases of the human central nervous system such as multiple sclerosis.|MSH2017_2016_08_12:An experimental animal model for central nervous system demyelinating disease. Inoculation with a white matter emulsion combined with FREUND'S ADJUVANT, myelin basic protein, or purified central myelin triggers a T cell-mediated immune response directed towards central myelin. The pathologic features are similar to MULTIPLE SCLEROSIS, including perivascular and periventricular foci of inflammation and demyelination. Subpial demyelination underlying meningeal infiltrations also occurs, which is also a feature of ENCEPHALOMYELITIS, ACUTE DISSEMINATED. Passive immunization with T-cells from an afflicted animal to a normal animal also induces this condition. (From Immunol Res 1998;17(1-2):217-27; Raine CS, Textbook of Neuropathology, 2nd ed, p604-5)|CSP2006:autoimmune disease that can be induced in various experimental animals by the injection of homogenised brain or spinal cord in Freund's adjuvant.
Version: v2
Suppressed: No

Names

Preferred names, aliases, and source labels retained in the final schema.

Name

Experimental Autoimmune Encephalomyelitis

Role

preferred

Name

Encephalomyelitis, Autoimmune, Experimental

Role

alias

Cross References

Trusted external identifiers retained for this final record.

Herb

HBDIS000917

Me Sh

D004681

Umls

C0014072

Sym Map

SMDE08552

Dis Ge Net

C0014072

Umls Sty

T050

Me Sh Class

C10C20

Tcmbank Disease

269576670

Itcmdb Generated

ITX-DISEASE-ED8B247838D2

Attributes

Merged source attributes and domain-specific metadata.

Version

Suppress

Disease Type

disease

Umls Disease Type

Experimental Model of Disease

Disease Definition

NCI2016_02D:An autoimmune demyelinating disease of the central nervous system that is produced experimentally in animals by the injection of homogenized brain or spinal cord in Freund's adjuvant. Myelin basic protein appears to be the antigen that elicits the hypersensitivity immune response which is characterized by focal areas of lymphocyte and macrophage infiltration into the brain, associated with demyelination and destruction of the blood-brain barrier. Experimental allergic encephalomyelitis (EAE) is used as an animal model for demyelinating diseases of the human central nervous system such as multiple sclerosis.|MSH2017_2016_08_12:An experimental animal model for central nervous system demyelinating disease. Inoculation with a white matter emulsion combined with FREUND'S ADJUVANT, myelin basic protein, or purified central myelin triggers a T cell-mediated immune response directed towards central myelin. The pathologic features are similar to MULTIPLE SCLEROSIS, including perivascular and periventricular foci of inflammation and demyelination. Subpial demyelination underlying meningeal infiltrations also occurs, which is also a feature of ENCEPHALOMYELITIS, ACUTE DISSEMINATED. Passive immunization with T-cells from an afflicted animal to a normal animal also induces this condition. (From Immunol Res 1998;17(1-2):217-27; Raine CS, Textbook of Neuropathology, 2nd ed, p604-5)|CSP2006:autoimmune disease that can be induced in various experimental animals by the injection of homogenised brain or spinal cord in Freund's adjuvant.

Me Sh Disease Class

Immune System Diseases; Nervous System Diseases

Dis Ge Net Disease Type

disease

Disease Class Name Me Sh

Immune System Diseases; Nervous System Diseases

Umls Semantic Type Name

Experimental Model of Disease